Protein: HUS1
Checkpoint protein HUS1 (hHUS1)

Gene: HUS1
Organism: Homo sapiens
Interactions: 73
UniProt ID: O60921

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261733

RAD9A
Cell cycle checkpoint control protein RAD9A

18

5

Small-scale

0.988

High

253180

RAD1
Cell cycle checkpoint protein RAD1

11

4

Small-scale

0.979

High

261683

RAD17
Cell cycle checkpoint protein RAD17

8

3

Small-scale

0.753

High

229292

ZBT14
Zinc finger and BTB domain-containing protein 14

3

1

High-throughput

0.667

High

261735

RHNO1
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

4

0

Small-scale

0.662

High

261704

FEN1
Flap endonuclease 1

3

0

Small-scale

0.639

High

261723

RAD9B
Cell cycle checkpoint control protein RAD9B

1

5

Small-scale

0.618

High

261706

RFC5
Replication factor C subunit 5

2

2

Small-scale

0.611

High

261680

SCN2B
Sodium channel regulatory subunit beta-2

3

1

High-throughput

0.609

High

261737

SLAF7
SLAM family member 7

3

2

High-throughput

0.609

High

140076

SDCB1
Syntenin-1

2

1

High-throughput

0.606

High

192674

ARPC5
Actin-related protein 2/3 complex subunit 5

2

0

High-throughput

0.602

High

261679

HUS1
Checkpoint protein HUS1

2

0

Small-scale

0.593

High

261722

CD046
Renal cancer differentiation gene 1 protein

2

0

High-throughput

0.580

High

261731

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

261736

DCNL5
DCN1-like protein 5

2

0

High-throughput

0.580

High

261743

GRIP1
Glutamate receptor-interacting protein 1

2

0

High-throughput

0.580

High

261720

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.573

High

261696

MSH3
DNA mismatch repair protein Msh3

1

2

Small-scale

0.561

High

261708

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.561

High

261712

MSH6
DNA mismatch repair protein Msh6

1

2

Small-scale

0.561

High

261728

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.561

High

261729

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.549

High

193359

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.537

High

261701

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.536

High

261702

RFC2
Replication factor C subunit 2

1

2

High-throughput

0.536

High

261692

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.529

High

261730

NEIL1
Endonuclease 8-like 1

1

0

Small-scale

0.513

High

261681

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

261682

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.513

High

261686

TNNC2
Troponin C, skeletal muscle

1

0

High-throughput

0.513

High

261690

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.513

High

261691

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

261709

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.513

High

261711

RBM25
RNA-binding protein 25

1

0

High-throughput

0.513

High

261734

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

261698

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

261684

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.493

High

261697

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.493

High

261689

DPOLB
DNA polymerase beta

1

0

Small-scale

0.480

High

261721

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.480

High

261726

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.480

High

261695

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.479

High

261703

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

261713

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

261715

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.479

High

261740

MUTYH
Adenine DNA glycosylase

1

2

Small-scale

0.479

High

187426

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

261687

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

261688

ALDOB
Fructose-bisphosphate aldolase B

1

0

High-throughput

0.458

High

261693

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.458

High

261694

DNLI1
DNA ligase 1

1

0

Small-scale

0.458

High

261699

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.458

High

261714

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.458

High

261717

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

261719

ATR
Serine/threonine-protein kinase ATR

1

0

Small-scale

0.458

High

261725

NIN
Ninein

1

0

High-throughput

0.458

High

261732

DNJC7
DnaJ homolog subfamily C member 7

1

0

Small-scale

0.458

High

261742

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.458

High

261718

SLAF1
Signaling lymphocytic activation molecule

1

2

High-throughput

0.437

High

261716

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.347

High

261724

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

0

High-throughput

0.345

High

261700

CD70
CD70 antigen

2

0

High-throughput

0.328

High

261705

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

261741

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

261707

OX2G
OX-2 membrane glycoprotein

1

0

High-throughput

0.282

High

261727

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.279

Low

261738

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

63720

PSD1
PH and SEC7 domain-containing protein 1

1

0

High-throughput

0.249

Low

261739

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

261685

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

261710

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025