HitPredict

Interactor 1: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	19557002, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005768 - endosome GO:0005802 - trans-Golgi network GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 141 Hs			1 236
+	Hs
		235129 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Hs
		212689 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	At
		1351793 VA721_ARATH (10-140): 2.62e-41: 138: 31.30		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		850607 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	Dm
		1178135 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	At
		812701 VA722_ARATH (10-139): 9.81e-40: 134: 33.08		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		212772 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Rn
		1144363 VAMP1_RAT (32-125): 5.09e-29: 103: 31.92		STX6_RAT (3-222): 3.2e-46: 155: 17.65
+	Dm
		577257 SYB_DROME (24-135): 9.5e-32: 112: 26.79		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		261624 VAMP4_HUMAN (1-120): 4.03e-40: 132: 100.00		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		320281 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Sc
		975941 NYV1_YEAST (11-136): 5.27e-27: 102: 25.00		TLG1_YEAST (2-220): 3.95e-32: 118: 15.07
+	Hs
		169416 VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Hs
		320265 VAMP1_HUMAN (32-125): 4.3e-28: 101: 30.85		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Sc
		701289 NYV1_YEAST (11-136): 5.27e-27: 102: 25.00		VAM7_YEAST (46-211): 1.29e-25: 103: 21.56
+	Sc
		611796 NYV1_YEAST (11-136): 5.27e-27: 102: 25.00		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Dm
		577224 SYB_DROME (24-135): 9.5e-32: 112: 26.79		Q7JRF1_DROME (3-138): 1.1e-20: 90.3: 14.29
+	Sc
		605819 SEC22_YEAST (23-133): 3.08e-25: 97: 17.12		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Dm
		1178137 Q7JYX5_DROME (15-138): 4.76e-36: 125: 27.42		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	Dm
		577258 SYB_DROME (24-135): 9.5e-32: 112: 26.79		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00