HitPredict

Interactor 1: ULK1 (O75385)
Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
Gene: ULK1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29251248, 35670107
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0031175 - neuron projection development
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1050 Hs			1 1319
+	Hs
		808172 MARK2_HUMAN (2-737): 1e-129: 414: 21.40		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808324 AKT3_HUMAN (1-351): 7.27e-129: 401: 23.06		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808229 MARK4_HUMAN (15-659): 1.85e-124: 399: 20.56		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		681731 AKT1_HUMAN (6-348): 1.31e-126: 396: 23.23		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808179 KCC1D_HUMAN (16-387): 7.81e-126: 390: 25.47		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		262307 ULK1_HUMAN (1-1050): 0: 807: 100.00		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1183099 MARK2_HUMAN (2-737): 1e-129: 414: 21.40		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1299664 AKT3_HUMAN (1-351): 7.27e-129: 401: 23.06		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		681988 AKT1_HUMAN (6-348): 1.31e-126: 396: 23.23		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1215924 KCC1D_HUMAN (16-387): 7.81e-126: 390: 25.47		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		200135 DAPK3_HUMAN (22-328): 8.6e-36: 144: 31.23		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Mm
		659462 KCC2B_MOUSE (14-555): 7.23e-133: 414: 20.50		HUWE1_MOUSE (799-1317): 8.82e-169: 561: 35.25
+	At
		1105338 KIN10_ARATH (15-397): 3.95e-133: 414: 25.65		UPL2_ARATH (837-1316): 9.11e-162: 540: 35.60
+	Sc
		419888 SNF1_YEAST (15-493): 6.95e-124: 394: 23.86		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41
+	Hs
		1183127 MARK2_HUMAN (2-737): 1e-129: 414: 21.40		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Sc
		765330 ATG1_YEAST (16-273): 4.5e-46: 181: 37.12		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41