Protein: COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)

Gene: COQ5
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q5HYK3

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix
GO:0006744 - ubiquinone biosynthetic process
GO:0008425 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1205109

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

4

High-throughput

0.618

High

1205159

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

2

1

Small-scale

0.584

High

879789

NPY2R
Neuropeptide Y receptor type 2

2

1

High-throughput

0.574

High

275035

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.561

High

1205158

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

1

High-throughput

0.561

High

279780

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

771139

APJ
Apelin receptor

2

2

High-throughput

0.549

High

1101502

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

1

High-throughput

0.549

High

532640

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.536

High

1205118

GTPB8
GTP-binding protein 8

1

1

High-throughput

0.536

High

262241

SCN2B
Sodium channel regulatory subunit beta-2

2

1

High-throughput

0.521

High

406892

MAS
Proto-oncogene Mas

1

4

High-throughput

0.489

High

638433

FPR1
fMet-Leu-Phe receptor

1

3

High-throughput

0.489

High

719789

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.489

High

1205137

CML1
Chemerin-like receptor 1

1

3

High-throughput

0.489

High

1205161

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

281968

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287303

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

471061

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

554803

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

856278

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

1083629

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1090421

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

1205114

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1205120

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.479

High

1205122

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.479

High

1205125

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

1205126

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1205127

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1205128

COQ8B
Atypical kinase COQ8B, mitochondrial

1

1

High-throughput

0.479

High

1205129

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1205131

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

1205133

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

3

High-throughput

0.479

High

1205135

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1205136

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1205138

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

1

High-throughput

0.479

High

1205139

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1205142

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1205154

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

4

High-throughput

0.479

High

1205156

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1205160

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

66211

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

301905

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.458

High

350886

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361638

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

828794

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841770

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851907

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

1011624

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.458

High

1048541

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058056

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1117748

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1123306

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1142561

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1205110

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1205116

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1205123

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.458

High

1205130

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1205132

PREY
Protein preY, mitochondrial

1

0

High-throughput

0.458

High

1205134

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1205143

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.458

High

1205145

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1205148

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1205149

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1205152

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1205153

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1205157

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1205146

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

653364

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

182564

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.407

High

538763

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

2

High-throughput

0.407

High

652198

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

2

High-throughput

0.407

High

1153393

CD226
CD226 antigen

1

1

High-throughput

0.407

High

1205124

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

1205150

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

2

High-throughput

0.407

High

1205115

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

0

High-throughput

0.345

High

1205121

F174A
Membrane protein FAM174A

3

0

High-throughput

0.345

High

1205155

CCG4
Voltage-dependent calcium channel gamma-4 subunit

2

0

High-throughput

0.318

High

754035

CD80
T-lymphocyte activation antigen CD80

2

0

High-throughput

0.313

High

848030

AL3B1
Aldehyde dehydrogenase family 3 member B1

2

0

High-throughput

0.313

High

1205119

MFD4A
Major facilitator superfamily domain-containing protein 4A

2

0

High-throughput

0.313

High

1205140

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.282

High

276592

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

596751

DPEP1
Dipeptidase 1

1

0

High-throughput

0.279

Low

713392

SPB3
Serpin B3

1

0

High-throughput

0.279

Low

749211

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

839564

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.279

Low

1053002

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.279

Low

1205113

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

1205117

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1205162

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

1205141

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

160894

STX16
Syntaxin-16

1

0

High-throughput

0.249

Low

293800

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

341589

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.249

Low

710282

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

1178171

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1205112

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

Small-scale

0.249

Low

1205147

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

379524

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

628413

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low

869490

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

High-throughput

0.232

Low

1177147

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.232

Low

1205111

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1205144

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.232

Low

1205151

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025