HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: STX2 (P32856)
Syntaxin-2 (Epimorphin)
Gene: STX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 288
+	Mm
		139056 SC22B_MOUSE (1-215): 6.45e-91: 267: 100.00		STX1A_MOUSE (1-287): 5.2e-78: 240: 65.63
+	Hs
		263248 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46
+	Hs
		263226 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX4_HUMAN (1-286): 1.23e-60: 196: 42.57
+	Dm
		115805 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		STX1A_DROME (2-282): 1.01e-72: 226: 60.56
+	Hs
		178331 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX7_HUMAN (36-284): 1.29e-48: 164: 27.78
+	Hs
		263279 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX12_HUMAN (26-270): 4.71e-48: 162: 25.00
+	At
		812702 VA722_ARATH (31-199): 6.71e-74: 224: 23.39		SY121_ARATH (17-265): 1.97e-54: 181: 22.96
+	At
		1378372 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY121_ARATH (17-265): 1.97e-54: 181: 22.96
+	Dm
		115812 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		STX4_DROME (16-266): 3.05e-51: 172: 21.51
+	At
		249598 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP41_ARATH (11-283): 3.61e-54: 180: 16.73
+	At
		1352876 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP43_ARATH (11-283): 1.75e-53: 178: 18.55
+	Dm
		115804 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		STX5_DROME (2-267): 7.54e-47: 164: 14.92
+	At
		1258650 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY132_ARATH (7-267): 1.34e-50: 170: 24.35
+	At
		1352985 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP42_ARATH (15-283): 2.42e-50: 170: 20.37
+	At
		1352937 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY122_ARATH (26-265): 1.21e-49: 169: 24.19
+	At
		955702 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP22_ARATH (15-271): 7.05e-48: 162: 18.66
+	At
		812689 VA722_ARATH (31-199): 6.71e-74: 224: 23.39		SY111_ARATH (4-265): 1.41e-44: 155: 21.69
+	At
		1114744 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY111_ARATH (4-265): 1.41e-44: 155: 21.69
+	At
		955681 VA713_ARATH (34-212): 5.8e-68: 209: 21.67		SYP22_ARATH (15-271): 7.05e-48: 162: 18.66
+	Sc
		605830 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		SSO1_YEAST (13-267): 3.07e-46: 158: 24.23