Protein: NOTC3
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]

Gene: NOTC3, NOTCH3
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9UM47

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054819

SUH
Recombining binding protein suppressor of hairless

5

9

Small-scale

0.929

High

1451422

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

12

High-throughput

0.871

High

582207

INGR1
Interferon gamma receptor 1

2

1

High-throughput

0.811

High

1250238

DLK2
Protein delta homolog 2

2

18

High-throughput

0.811

High

1331020

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

4

15

High-throughput

0.797

High

568017

PRG2
Bone marrow proteoglycan

2

11

High-throughput

0.776

High

1047781

NOTC2
Neurogenic locus notch homolog protein 2

2

19

High-throughput

0.776

High

1008030

JAG1
Protein jagged-1

2

17

Small-scale

0.768

High

132372

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

14

Small-scale

0.747

High

1459916

EGFL7
Epidermal growth factor-like protein 7

2

20

Small-scale

0.744

High

177336

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

16

High-throughput

0.698

High

1417986

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.698

High

1461968

NOTC3
Neurogenic locus notch homolog protein 3

1

17

Small-scale

0.692

High

239342

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

20

High-throughput

0.691

High

857591

NOTC1
Neurogenic locus notch homolog protein 1

1

17

High-throughput

0.691

High

1438493

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.691

High

1449418

IGSF5
Immunoglobulin superfamily member 5

1

2

High-throughput

0.691

High

1460861

FBX2
F-box only protein 2

1

11

High-throughput

0.691

High

1461972

ST14
Suppressor of tumorigenicity 14 protein

1

9

High-throughput

0.691

High

252731

TSN3
Tetraspanin-3

3

1

High-throughput

0.667

High

921582

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

1

High-throughput

0.667

High

139662

DLL1
Delta-like protein 1

1

14

Small-scale

0.647

High

250362

VINEX
Vinexin

1

7

Small-scale

0.647

High

1127376

CASL
Enhancer of filamentation 1

1

4

Small-scale

0.647

High

1132071

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

20

Small-scale

0.647

High

1365159

MAML1
Mastermind-like protein 1

1

13

Small-scale

0.647

High

1461969

JAG2
Protein jagged-2

1

20

Small-scale

0.647

High

1461971

NEUR2
Sialidase-2

3

0

High-throughput

0.638

High

1349413

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

2

7

High-throughput

0.628

High

1453403

ZN224
Zinc finger protein 224

2

5

High-throughput

0.628

High

654568

FBLN1
Fibulin-1

1

19

High-throughput

0.621

High

1249767

BTNL3
Butyrophilin-like protein 3

1

4

High-throughput

0.618

High

362408

ABL1
Tyrosine-protein kinase ABL1

1

9

High-throughput

0.618

High

594135

NCK1
SH2/SH3 adapter protein NCK1

1

5

High-throughput

0.618

High

891880

GSK3B
Glycogen synthase kinase-3 beta

1

11

Small-scale

0.618

High

1060935

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

9

Small-scale

0.618

High

1114643

CUL3
Cullin-3

1

15

High-throughput

0.618

High

1331477

ZFP41
Zinc finger protein 41 homolog

3

19

High-throughput

0.609

High

948030

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

1357049

S20A1
Sodium-dependent phosphate transporter 1

2

0

High-throughput

0.602

High

1431430

ABCG8
ATP-binding cassette sub-family G member 8

2

0

High-throughput

0.602

High

480931

LEG1
Galectin-1

2

6

High-throughput

0.601

High

915912

CRIP2
Cysteine-rich protein 2

1

3

Small-scale

0.579

High

1312090

DJC10
DnaJ homolog subfamily C member 10

2

3

High-throughput

0.574

High

1395235

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

6

High-throughput

0.574

High

1419459

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

13

High-throughput

0.574

High

1437017

ZN408
Zinc finger protein 408

2

20

High-throughput

0.574

High

885450

HXA1
Homeobox protein Hox-A1

1

20

High-throughput

0.541

High

1277967

NUFP2
FMR1-interacting protein NUFIP2

1

2

High-throughput

0.541

High

1460485

MBD1
Methyl-CpG-binding domain protein 1

1

4

High-throughput

0.541

High

1051688

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

1

High-throughput

0.536

High

1103115

MFAP5
Microfibrillar-associated protein 5

1

3

High-throughput

0.536

High

1159279

ZNF74
Zinc finger protein 74

1

19

High-throughput

0.536

High

1349907

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

5

High-throughput

0.536

High

1355971

NET5
Netrin-5

1

15

High-throughput

0.536

High

1435448

EGLN3
Prolyl hydroxylase EGLN3

1

7

High-throughput

0.536

High

561010

IL7
Interleukin-7

1

0

High-throughput

0.513

High

1277994

KCNKI
Potassium channel subfamily K member 18

1

0

High-throughput

0.513

High

1461973

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

995347

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

343533

CPNE6
Copine-6

1

1

Small-scale

0.501

High

347412

BAG2
BAG family molecular chaperone regulator 2

1

1

Small-scale

0.501

High

373482

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.501

High

464078

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.501

High

986812

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

Small-scale

0.501

High

1111356

SNW1
SNW domain-containing protein 1

1

1

Small-scale

0.501

High

1452207

S39A1
Zinc transporter ZIP1

1

4

Small-scale

0.501

High

1249692

IGFL3
Insulin growth factor-like family member 3

1

4

High-throughput

0.489

High

1334621

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.489

High

1385471

ZN707
Zinc finger protein 707

1

20

High-throughput

0.489

High

185048

SPTC2
Serine palmitoyltransferase 2

1

0

Small-scale

0.480

High

216200

MTG8R
Protein CBFA2T2

1

0

Small-scale

0.480

High

567518

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.480

High

852128

TNNT2
Troponin T, cardiac muscle

1

0

Small-scale

0.480

High

1388335

RMI2
RecQ-mediated genome instability protein 2

1

0

Small-scale

0.480

High

1434888

XKR8
XK-related protein 8

1

0

Small-scale

0.480

High

218955

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

412799

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

556418

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

651463

CBL
E3 ubiquitin-protein ligase CBL

1

5

Small-scale

0.479

High

832613

CASR
Extracellular calcium-sensing receptor

1

2

Small-scale

0.479

High

1131151

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

12

Small-scale

0.479

High

1289337

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

8

High-throughput

0.479

High

1367581

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1461970

STRAP
Serine-threonine kinase receptor-associated protein

1

10

Small-scale

0.479

High

1017683

PR20D
Proline-rich protein 20D

1

2

High-throughput

0.470

High

681075

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.458

High

1235243

PTCRA
Pre T-cell antigen receptor alpha

1

0

Small-scale

0.458

High

299892

C1QRF
C1q-related factor

1

1

Small-scale

0.457

High

1225872

WDR25
WD repeat-containing protein 25

1

10

Small-scale

0.457

High

1364098

SNX19
Sorting nexin-19

1

1

Small-scale

0.457

High

1395612

BT3L4
Transcription factor BTF3 homolog 4

1

2

Small-scale

0.457

High

143490

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

933499

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.445

High

1310980

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

8

High-throughput

0.445

High

1323783

S39AB
Zinc transporter ZIP11

1

4

High-throughput

0.445

High

1335436

SPX3
Sugar phosphate exchanger 3

1

4

High-throughput

0.445

High

1449280

S22AB
Solute carrier family 22 member 11

1

3

High-throughput

0.445

High

1017761

PR20A
Proline-rich protein 20A

1

2

High-throughput

0.439

High

1432220

SPNS1
Protein spinster homolog 1

1

2

High-throughput

0.407

High

1436391

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

952514

CTXN1
Cortexin-1

1

0

High-throughput

0.279

Low

1153701

MPPD2
Metallophosphoesterase MPPED2

1

0

Small-scale

0.261

Low

1242537

GGT6
Glutathione hydrolase 6

1

0

Small-scale

0.261

Low

1249780

TM108
Transmembrane protein 108

1

0

Small-scale

0.261

Low

1330807

CNTD1
Cyclin N-terminal domain-containing protein 1

1

0

Small-scale

0.261

Low

1395649

CH076
Uncharacterized protein C8orf76

1

0

Small-scale

0.261

Low

1400961

SG3A1
Secretoglobin family 3A member 1

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025