Protein: NMDZ1
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) (hNR1)

Gene: NMDZ1, GRIN1
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q05586

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0004972 - NMDA glutamate receptor activity
GO:0005509 - calcium ion binding
GO:0005516 - calmodulin binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051656

NMDE1
Glutamate receptor ionotropic, NMDA 2A

14

20

Small-scale

0.978

High

1051658

NMDE2
Glutamate receptor ionotropic, NMDA 2B

10

20

Small-scale

0.969

High

248437

NMD3B
Glutamate receptor ionotropic, NMDA 3B

2

19

Small-scale

0.754

High

1051676

NMD3A
Glutamate receptor ionotropic, NMDA 3A

2

20

Small-scale

0.754

High

1006051

DLG4
Disks large homolog 4

4

20

Small-scale

0.680

High

421971

A4
Amyloid-beta precursor protein

3

10

Small-scale

0.670

High

1051654

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

20

Small-scale

0.647

High

189316

NMDE4
Glutamate receptor ionotropic, NMDA 2D

1

18

Small-scale

0.618

High

835436

GRM5
Metabotropic glutamate receptor 5

1

20

Small-scale

0.618

High

1051661

LRP8
Low-density lipoprotein receptor-related protein 8

1

4

Small-scale

0.618

High

1051663

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

20

Small-scale

0.618

High

1051677

NETO1
Neuropilin and tolloid-like protein 1

1

7

Small-scale

0.618

High

1051660

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

14

Small-scale

0.550

High

669267

PTAFR
Platelet-activating factor receptor

1

9

High-throughput

0.541

High

858190

BKRB1
B1 bradykinin receptor

1

7

High-throughput

0.541

High

1051662

DOCK1
Dedicator of cytokinesis protein 1

1

3

High-throughput

0.536

High

1051665

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

9

High-throughput

0.536

High

1051672

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

High-throughput

0.536

High

1051673

AN13C
Ankyrin repeat domain-containing protein 13C

1

1

High-throughput

0.536

High

1051674

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

2

High-throughput

0.536

High

1051679

ELMO1
Engulfment and cell motility protein 1

1

1

High-throughput

0.536

High

1051680

CDS1
Phosphatidate cytidylyltransferase 1

1

1

High-throughput

0.536

High

1051684

BC11B
B-cell lymphoma/leukemia 11B

1

1

High-throughput

0.536

High

1051686

DOCK5
Dedicator of cytokinesis protein 5

1

3

High-throughput

0.536

High

1051687

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

1051688

NOTC3
Neurogenic locus notch homolog protein 3

1

1

High-throughput

0.536

High

1051675

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.527

High

1051685

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.513

High

440504

FYN
Tyrosine-protein kinase Fyn

1

12

Small-scale

0.501

High

603246

KPCA
Protein kinase C alpha type

1

13

Small-scale

0.501

High

1051657

DLG1
Disks large homolog 1

1

20

Small-scale

0.501

High

1051659

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

16

Small-scale

0.501

High

1051681

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.489

High

1051682

NR1H4
Bile acid receptor

1

3

Small-scale

0.481

High

224696

ACTN4
Alpha-actinin-4

1

9

Small-scale

0.479

High

241470

PRKN
E3 ubiquitin-protein ligase parkin

1

6

Small-scale

0.479

High

506592

GPHRB
Golgi pH regulator B

1

1

High-throughput

0.479

High

698600

CALX
Calnexin

1

2

Small-scale

0.479

High

710816

EPHB2
Ephrin type-B receptor 2

1

3

Small-scale

0.479

High

773729

ACTN2
Alpha-actinin-2

1

9

Small-scale

0.479

High

845014

EAA3
Excitatory amino acid transporter 3

1

4

Small-scale

0.479

High

907308

APLP1
Amyloid beta precursor like protein 1

1

9

Small-scale

0.479

High

928766

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

1

Small-scale

0.479

High

1051655

APLP2
Amyloid beta precursor like protein 2

1

9

Small-scale

0.479

High

1051664

PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

1

3

Small-scale

0.479

High

1051666

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

10

Small-scale

0.479

High

1051667

NTRK2
BDNF/NT-3 growth factors receptor

1

5

Small-scale

0.479

High

1051668

DCAF6
DDB1- and CUL4-associated factor 6

1

2

High-throughput

0.479

High

1051670

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1051689

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

16

Small-scale

0.479

High

775027

FUS
RNA-binding protein FUS

1

2

High-throughput

0.470

High

297298

RGS9
Regulator of G-protein signaling 9

1

0

Small-scale

0.458

High

1051683

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

Small-scale

0.458

High

85358

GPHRA
Golgi pH regulator A

1

1

High-throughput

0.445

High

105800

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1051678

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

8

High-throughput

0.437

High

1051669

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

0

High-throughput

0.279

Low

397639

NU2M
NADH-ubiquinone oxidoreductase chain 2

1

0

Small-scale

0.249

Low

1051671

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025