HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	27705803, 11171983, 24981860
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 281 Hs			1 406
+	Hs
		963597 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Mm
		222619 E2F6_MOUSE (1-272): 3.68e-95: 283: 87.13		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		265700 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Mm
		1257625 Q8VHT4_MOUSE (37-272): 1.09e-86: 260: 88.14		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		987969 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		1050532 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		265610 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		265611 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37
+	Hs
		265707 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		1051778 E2F2_HUMAN (3-274): 1.57e-92: 282: 37.42		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		265705 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		265660 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53
+	Hs
		265673 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33
+	Hs
		135283 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		963679 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		749384 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		1071528 E2F5_HUMAN (61-273): 4.61e-72: 226: 34.51		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		1081395 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		749536 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		1050537 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08