HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: LMBL2 (Q969R5)
Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)
Gene: L3MBTL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	27705803, 33961781, 21596310, 26186194, 28514442, 24981860
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 705
+	Mm
		222616 E2F6_MOUSE (1-272): 3.68e-95: 283: 87.13		LMBL2_MOUSE (1-705): 0: 1001: 90.92
+	Hs
		135276 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Hs
		1050527 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Mm
		886480 TFDP1_MOUSE (4-232): 1.8e-59: 196: 17.30		LMBL2_MOUSE (1-705): 0: 1001: 90.92
+	Hs
		1050564 TFDP2_HUMAN (4-232): 2.88e-52: 178: 14.64		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Hs
		135299 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		SMBT1_HUMAN (160-638): 0: 556: 32.19
+	Hs
		265697 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Hs
		1051775 E2F2_HUMAN (3-274): 1.57e-92: 282: 37.42		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Hs
		135277 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Hs
		963668 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Hs
		963710 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		LMBL1_HUMAN (140-323): 1.62e-24: 111: 21.74
+	Hs
		1081363 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Dm
		1099755 E2F1_DROME (7-270): 2.83e-63: 214: 26.51		Q9VB52_DROME (148-294): 5.52e-17: 87.9: 22.45
+	Dm
		1097284 TFDP_DROME (36-232): 3.08e-40: 146: 17.59		SMBT_DROME (138-401): 4.84e-35: 145: 21.17