Protein: FGD5
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)

Gene: FGD5
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q6ZNL6

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

902942

DCAF7
DDB1- and CUL4-associated factor 7

2

8

High-throughput

0.737

High

950511

ARF1
ADP-ribosylation factor 1

2

7

High-throughput

0.737

High

1169507

DBNL
Drebrin-like protein

2

19

High-throughput

0.737

High

610739

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

3

High-throughput

0.691

High

338594

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.681

High

919135

RAN
GTP-binding nuclear protein Ran

1

12

High-throughput

0.665

High

925376

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

435676

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

441526

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.618

High

929519

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.618

High

1021675

MYO1E
Unconventional myosin-Ie

1

20

High-throughput

0.618

High

1045439

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.618

High

1167373

MPRIP
Myosin phosphatase Rho-interacting protein

1

20

High-throughput

0.618

High

1169516

MRCKB
Serine/threonine-protein kinase MRCK beta

1

12

High-throughput

0.618

High

1068579

PLEC
Plectin

2

20

High-throughput

0.601

High

1169494

PHB2
Prohibitin-2

2

3

High-throughput

0.601

High

882380

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

15

High-throughput

0.575

High

203720

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.549

High

529311

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.541

High

1169508

AKA11
A-kinase anchor protein 11

1

1

High-throughput

0.536

High

627288

MCM3
DNA replication licensing factor MCM3

2

9

High-throughput

0.521

High

1027073

CBX3
Chromobox protein homolog 3

2

3

High-throughput

0.521

High

910472

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.515

High

263688

PR40A
Pre-mRNA-processing factor 40 homolog A

1

15

High-throughput

0.515

High

527556

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.515

High

877076

CASP6
Caspase-6

1

0

High-throughput

0.493

High

1157324

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.486

High

117738

MYO1C
Unconventional myosin-Ic

1

19

High-throughput

0.479

High

121799

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.479

High

149663

COPE
Coatomer subunit epsilon

1

4

High-throughput

0.479

High

161392

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

15

High-throughput

0.479

High

168941

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

211602

ACTN4
Alpha-actinin-4

1

14

High-throughput

0.479

High

214608

MYO1B
Unconventional myosin-Ib

1

20

High-throughput

0.479

High

261287

FLNB
Filamin-B

1

20

High-throughput

0.479

High

279603

FLOT1
Flotillin-1

1

12

High-throughput

0.479

High

313847

SVIL
Supervillin

1

11

High-throughput

0.479

High

320874

HS74L
Heat shock 70 kDa protein 4L

1

8

High-throughput

0.479

High

322789

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

334223

LDHA
L-lactate dehydrogenase A chain

1

5

High-throughput

0.479

High

359375

K1C14
Keratin, type I cytoskeletal 14

1

7

High-throughput

0.479

High

359505

K2C6A
Keratin, type II cytoskeletal 6A

1

7

High-throughput

0.479

High

375962

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

377415

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

380491

K2C6B
Keratin, type II cytoskeletal 6B

1

7

High-throughput

0.479

High

380638

K2C1
Keratin, type II cytoskeletal 1

1

6

High-throughput

0.479

High

398722

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

1

High-throughput

0.479

High

408843

K1C18
Keratin, type I cytoskeletal 18

1

7

High-throughput

0.479

High

409127

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

413965

GELS
Gelsolin

1

11

High-throughput

0.479

High

415383

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.479

High

417325

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

422044

LDHB
L-lactate dehydrogenase B chain

1

5

High-throughput

0.479

High

423269

PDIA1
Protein disulfide-isomerase

1

7

High-throughput

0.479

High

427595

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

428266

TBB5
Tubulin beta chain

1

8

High-throughput

0.479

High

431982

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

438290

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

444545

K2C7
Keratin, type II cytoskeletal 7

1

5

High-throughput

0.479

High

445074

K1C16
Keratin, type I cytoskeletal 16

1

7

High-throughput

0.479

High

445450

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

447689

ENOG
Gamma-enolase

1

2

High-throughput

0.479

High

499856

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

502249

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

504276

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

516565

PABP1
Polyadenylate-binding protein 1

1

8

High-throughput

0.479

High

518691

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

519342

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

8

High-throughput

0.479

High

521566

ACTN1
Alpha-actinin-1

1

14

High-throughput

0.479

High

523830

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

531385

K1C10
Keratin, type I cytoskeletal 10

1

8

High-throughput

0.479

High

531592

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.479

High

531875

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.479

High

536385

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.479

High

537939

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

538677

MYL6B
Myosin light chain 6B

1

6

High-throughput

0.479

High

541377

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

550833

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

573326

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.479

High

575089

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.479

High

580661

ML12A
Myosin regulatory light chain 12A

1

6

High-throughput

0.479

High

582347

NUCL
Nucleolin

1

7

High-throughput

0.479

High

598185

FLNA
Filamin-A

1

20

High-throughput

0.479

High

616380

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

617861

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.479

High

623950

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

2

High-throughput

0.479

High

624359

MYL9
Myosin regulatory light polypeptide 9

1

6

High-throughput

0.479

High

636970

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

644073

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

647024

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

653999

MAP4
Microtubule-associated protein 4

1

5

High-throughput

0.479

High

666925

TKT
Transketolase

1

1

High-throughput

0.479

High

685712

PRDX2
Peroxiredoxin-2

1

6

High-throughput

0.479

High

702926

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.479

High

714272

HSP74
Heat shock 70 kDa protein 4

1

8

High-throughput

0.479

High

724098

K1C9
Keratin, type I cytoskeletal 9

1

7

High-throughput

0.479

High

724887

MYH9
Myosin-9

1

12

High-throughput

0.479

High

725184

MYH10
Myosin-10

1

12

High-throughput

0.479

High

728488

MYH11
Myosin-11

1

12

High-throughput

0.479

High

729119

K22E
Keratin, type II cytoskeletal 2 epidermal

1

7

High-throughput

0.479

High

751691

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

770900

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.479

High

777608

MDHM
Malate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

783060

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

789854

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

809135

UTRN
Utrophin

1

20

High-throughput

0.479

High

809344

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

9

High-throughput

0.479

High

813561

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

821277

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.479

High

825983

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

826729

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.479

High

827446

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

842923

TCPQ
T-complex protein 1 subunit theta

1

7

High-throughput

0.479

High

843255

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.479

High

849117

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.479

High

849224

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

3

High-throughput

0.479

High

853337

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.479

High

862418

ACLY
ATP-citrate synthase

1

3

High-throughput

0.479

High

875048

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

875996

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

2

High-throughput

0.479

High

879278

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.479

High

891546

MYL6
Myosin light polypeptide 6

1

6

High-throughput

0.479

High

891852

ACTB
Actin, cytoplasmic 1

1

17

High-throughput

0.479

High

898364

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

905981

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

High-throughput

0.479

High

906509

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

20

High-throughput

0.479

High

909711

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.479

High

913593

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

915000

RS4X
Small ribosomal subunit protein eS4, X isoform

1

3

High-throughput

0.479

High

925922

AP2B1
AP-2 complex subunit beta

1

12

High-throughput

0.479

High

931231

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.479

High

932015

TPM4
Tropomyosin alpha-4 chain

1

5

High-throughput

0.479

High

932218

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.479

High

932756

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.479

High

933004

ACTS
Actin, alpha skeletal muscle

1

7

High-throughput

0.479

High

933245

TBA1B
Tubulin alpha-1B chain

1

9

High-throughput

0.479

High

933860

TBB4B
Tubulin beta-4B chain

1

8

High-throughput

0.479

High

942188

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

943308

TCPB
T-complex protein 1 subunit beta

1

6

High-throughput

0.479

High

960853

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.479

High

973111

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

974098

DYST
Dystonin

1

20

High-throughput

0.479

High

979930

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.479

High

980275

K1C17
Keratin, type I cytoskeletal 17

1

7

High-throughput

0.479

High

984373

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.479

High

984614

CALD1
Caldesmon

1

20

High-throughput

0.479

High

990872

ZO1
Tight junction protein ZO-1

1

11

High-throughput

0.479

High

999611

AHNK
Neuroblast differentiation-associated protein AHNAK

1

8

High-throughput

0.479

High

1022525

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

5

High-throughput

0.479

High

1023185

FLII
Protein flightless-1 homolog

1

14

High-throughput

0.479

High

1027707

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

1046495

TBB2A
Tubulin beta-2A chain

1

8

High-throughput

0.479

High

1051584

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

4

High-throughput

0.479

High

1052892

FLNC
Filamin-C

1

20

High-throughput

0.479

High

1062832

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

1063148

SEPT2
Septin-2

1

6

High-throughput

0.479

High

1069310

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.479

High

1080948

SEPT7
Septin-7

1

6

High-throughput

0.479

High

1082243

DDB1
DNA damage-binding protein 1

1

3

High-throughput

0.479

High

1083109

DPYL2
Dihydropyrimidinase-related protein 2

1

7

High-throughput

0.479

High

1084981

DREB
Drebrin

1

8

High-throughput

0.479

High

1121302

AGK
Acylglycerol kinase, mitochondrial

1

2

High-throughput

0.479

High

1148922

CYTSA
Cytospin-A

1

20

High-throughput

0.479

High

1169485

TBA1A
Tubulin alpha-1A chain

1

9

High-throughput

0.479

High

1169486

MYH14
Myosin-14

1

12

High-throughput

0.479

High

1169487

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.479

High

1169489

LMO7
LIM domain only protein 7

1

11

High-throughput

0.479

High

1169490

MY18A
Unconventional myosin-XVIIIa

1

20

High-throughput

0.479

High

1169492

DOCK7
Dedicator of cytokinesis protein 7

1

5

High-throughput

0.479

High

1169493

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

High-throughput

0.479

High

1169495

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.479

High

1169496

TCPH
T-complex protein 1 subunit eta

1

6

High-throughput

0.479

High

1169497

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1169499

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

20

High-throughput

0.479

High

1169501

TMOD3
Tropomodulin-3

1

10

High-throughput

0.479

High

1169502

RAI14
Ankycorbin

1

20

High-throughput

0.479

High

1169503

RRBP1
Ribosome-binding protein 1

1

20

High-throughput

0.479

High

1169504

ZO2
Tight junction protein ZO-2

1

11

High-throughput

0.479

High

1169505

LIMA1
LIM domain and actin-binding protein 1

1

10

High-throughput

0.479

High

1169506

SEPT9
Septin-9

1

6

High-throughput

0.479

High

1169509

MYO6
Unconventional myosin-VI

1

17

High-throughput

0.479

High

1169510

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.479

High

1169511

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

20

High-throughput

0.479

High

1169512

LIMC1
LIM and calponin homology domains-containing protein 1

1

6

High-throughput

0.479

High

1169513

RTRAF
RNA transcription, translation and transport factor protein

1

2

High-throughput

0.479

High

1169514

PLAK2
PALM2-AKAP2 fusion protein

1

3

High-throughput

0.479

High

1169515

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

1169519

MYH4
Myosin-4

1

12

High-throughput

0.479

High

337244

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

363826

ALBU
Albumin

1

0

High-throughput

0.458

High

382039

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

434492

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.458

High

606438

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

669405

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

808027

GNPI1
Glucosamine-6-phosphate isomerase 1

1

0

High-throughput

0.458

High

888181

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

966720

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1169491

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.458

High

1169498

TMM43
Transmembrane protein 43

1

0

High-throughput

0.458

High

1169518

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.458

High

100877

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

519795

KCRU
Creatine kinase U-type, mitochondrial

1

1

High-throughput

0.437

High

533483

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

778192

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.437

High

935944

NOMO3
BOS complex subunit NOMO3

1

2

High-throughput

0.437

High

1069012

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.437

High

1169500

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

1

High-throughput

0.437

High

1169517

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

20

High-throughput

0.437

High

678006

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

3

0

High-throughput

0.330

High

1169488

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

517323

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024