HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 24457600, 26496610, 23280602, 27338022, 28320739, 27705803, 9584197, 10581039, 9742080, 32296183, 31786184, 31527584, 24981860, 12435631, 15385962, 15225548, 35636260, 37071682, 19026781, 19026780 and 30 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, biochemical, cross-linking study, enzymatic study, anti tag coimmunoprecipitation, validated two hybrid, anti bait coimmunoprecipitation, tandem affinity purification and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains EZH2_WD-Binding~WD40, SET~WD40
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001222 - transcription corepressor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0035098 - ESC/E(Z) complex
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 441
Hs

1 746
+ Mm
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+ Dm
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+ Ce
+ Mm
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+ Hs
+ Mm
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+ Zm
+ At
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+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024