HitPredict

Interactor 1: DAB1 (O75553)
Disabled homolog 1
Gene: DAB1

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 588 Hs			1 1255
+	Hs
		383867 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383908 ANS1A_HUMAN (11-241): 2.96e-38: 153: 17.02		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Mm
		956223 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		EGFR_MOUSE (17-1254): 0: 1126: 48.48
+	Hs
		269121 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		1070979 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		1070992 ANS1A_HUMAN (11-241): 2.96e-38: 153: 17.02		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		338128 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338632 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338279 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338786 ANS1A_HUMAN (11-241): 2.96e-38: 153: 17.02		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		339214 NUMBL_HUMAN (3-574): 6.05e-39: 153: 12.50		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		434160 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		434325 NUMBL_HUMAN (3-574): 6.05e-39: 153: 12.50		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		665562 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47
+	Hs
		833598 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61
+	Hs
		833553 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45
+	Hs
		833552 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46
+	Mm
		1206693 ANS1B_MOUSE (9-236): 2.44e-42: 165: 15.95		FAK2_MOUSE (707-1006): 9.29e-54: 207: 36.42
+	Hs
		435585 NUMB_HUMAN (4-549): 1.69e-46: 175: 15.64		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Hs
		435814 NUMBL_HUMAN (3-574): 6.05e-39: 153: 12.50		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92