Protein: USF1
Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)

Gene: USF1
Organism: Homo sapiens
Interactions: 97
UniProt ID: P22415

Gene Ontology (top 5):
GO:0000430 - regulation of transcription from RNA polymerase II promoter by glucose
GO:0000432 - positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

648363

USF2
Upstream stimulatory factor 2

10

19

Small-scale

0.975

High

648325

USF1
Upstream stimulatory factor 1

6

18

Small-scale

0.952

High

648359

FHL2
Four and a half LIM domains protein 2

2

12

High-throughput

0.811

High

583994

FOSL1
Fos-related antigen 1

5

20

Small-scale

0.729

High

587416

TFE2
Transcription factor E2-alpha

1

6

Small-scale

0.713

High

648332

SRBP1
Sterol regulatory element-binding protein 1

1

18

Small-scale

0.691

High

648387

TCFL5
Transcription factor-like 5 protein

1

0

Small-scale

0.687

High

648347

GTF2I
General transcription factor II-I

4

3

Small-scale

0.683

High

648330

C2TA
MHC class II transactivator

4

5

Small-scale

0.683

High

501913

H2AZ
Histone H2A.Z

1

13

High-throughput

0.665

High

648375

TRI11
E3 ubiquitin-protein ligase TRIM11

2

4

High-throughput

0.628

High

648381

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

17

High-throughput

0.628

High

604884

HXB4
Homeobox protein Hox-B4

1

8

Small-scale

0.618

High

648342

MAX
Protein max

1

18

Small-scale

0.618

High

648346

H31
Histone H3.1

1

11

High-throughput

0.618

High

648349

H33
Histone H3.3

1

11

High-throughput

0.618

High

648368

H2AV
Histone H2A.V

1

13

High-throughput

0.618

High

648340

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

3

5

High-throughput

0.609

High

648328

AMPL
Cytosol aminopeptidase

2

2

High-throughput

0.606

High

648339

M3KCL
MAP3K7 C-terminal-like protein

2

1

High-throughput

0.606

High

648358

SNW1
SNW domain-containing protein 1

2

2

High-throughput

0.606

High

639187

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

3

Small-scale

0.601

High

175837

SET1A
Histone-lysine N-methyltransferase SETD1A

2

10

Small-scale

0.584

High

648327

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

2

20

Small-scale

0.584

High

648336

TAF6
Transcription initiation factor TFIID subunit 6

2

1

Small-scale

0.584

High

648337

HCFC1
Host cell factor 1

2

8

Small-scale

0.584

High

648344

WDR5
WD repeat-containing protein 5

2

20

Small-scale

0.584

High

648353

RBBP4
Histone-binding protein RBBP4

2

17

Small-scale

0.584

High

648355

TF3C1
General transcription factor 3C polypeptide 1

2

2

Small-scale

0.584

High

648356

BPTF
Nucleosome-remodeling factor subunit BPTF

2

20

Small-scale

0.584

High

648360

RBBP5
Retinoblastoma-binding protein 5

2

20

Small-scale

0.584

High

648377

ANM1
Protein arginine N-methyltransferase 1

2

10

Small-scale

0.584

High

648380

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

20

Small-scale

0.584

High

648384

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

2

14

Small-scale

0.584

High

648393

TRRAP
Transformation/transcription domain-associated protein

2

16

Small-scale

0.584

High

648373

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.579

High

648357

TRAF2
TNF receptor-associated factor 2

1

7

High-throughput

0.573

High

486957

PARP1
Poly [ADP-ribose] polymerase 1

1

12

Small-scale

0.554

High

557864

XRCC6
X-ray repair cross-complementing protein 6

1

7

Small-scale

0.554

High

559219

XRCC5
X-ray repair cross-complementing protein 5

1

7

Small-scale

0.554

High

648348

PRKDC
DNA-dependent protein kinase catalytic subunit

1

16

Small-scale

0.554

High

648351

TOP2B
DNA topoisomerase 2-beta

1

4

Small-scale

0.554

High

321820

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

4

High-throughput

0.536

High

369017

ASSY
Argininosuccinate synthase

1

3

High-throughput

0.536

High

648329

PML
Protein PML

1

14

High-throughput

0.536

High

648366

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.536

High

648378

ZN644
Zinc finger protein 644

1

4

High-throughput

0.536

High

648390

DICER
Endoribonuclease Dicer

1

14

High-throughput

0.536

High

648391

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

4

High-throughput

0.536

High

648343

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.534

High

648341

CXCR4
C-X-C chemokine receptor type 4

1

4

Small-scale

0.515

High

374402

RASH
GTPase HRas

1

9

High-throughput

0.515

High

648326

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.515

High

648367

Q6FG41
Protein c-Fos

1

20

High-throughput

0.515

High

648389

UBQL1
Ubiquilin-1

1

6

High-throughput

0.515

High

648365

ESCO2
N-acetyltransferase ESCO2

1

0

High-throughput

0.513

High

648374

EME1
Structure-specific endonuclease subunit EME1

1

0

High-throughput

0.513

High

421507

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

648383

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

2

Small-scale

0.501

High

648388

TAOK2
Serine/threonine-protein kinase TAO2

1

9

Small-scale

0.501

High

648392

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

269435

KI21B
Kinesin-like protein KIF21B

1

7

High-throughput

0.489

High

298664

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.489

High

648334

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.489

High

648338

PLXA3
Plexin-A3

1

1

High-throughput

0.489

High

648352

KLC1
Kinesin light chain 1

1

7

High-throughput

0.489

High

648394

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

2

High-throughput

0.489

High

648386

HDAC9
Histone deacetylase 9

1

20

Small-scale

0.484

High

370563

FOS
Protein c-Fos

1

20

High-throughput

0.481

High

648370

HOMEZ
Homeobox and leucine zipper protein Homez

1

7

High-throughput

0.481

High

130378

SPT5H
Transcription elongation factor SPT5

1

9

Small-scale

0.479

High

143393

E2F3
Transcription factor E2F3

1

7

Small-scale

0.479

High

243541

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.479

High

347529

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

549428

CD20
B-lymphocyte antigen CD20

1

1

Small-scale

0.479

High

648333

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

18

Small-scale

0.479

High

648335

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.479

High

648345

H4
Histone H4

1

15

High-throughput

0.479

High

648350

EWS
RNA-binding protein EWS

1

16

High-throughput

0.479

High

648354

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

648361

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

9

Small-scale

0.479

High

648362

TAF7
Transcription initiation factor TFIID subunit 7

1

2

Small-scale

0.479

High

648364

RBBP7
Histone-binding protein RBBP7

1

19

Small-scale

0.479

High

648372

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

648376

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

648385

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

3

Small-scale

0.479

High

648379

PKHF2
Pleckstrin homology domain-containing family F member 2

1

4

High-throughput

0.464

High

360375

COX2
Cytochrome c oxidase subunit 2

1

3

High-throughput

0.445

High

648331

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

14

Small-scale

0.445

High

543409

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

7

High-throughput

0.437

High

634943

MIME
Mimecan

1

4

Small-scale

0.437

High

648369

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

5

High-throughput

0.437

High

648395

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

2

High-throughput

0.437

High

116937

J3KNB8
Mitogen-activated protein kinase kinase kinase 4

1

2

High-throughput

0.407

High

648371

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

648382

TRM13
tRNA:m(4)X modification enzyme TRM13 homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025