Protein: UBP5
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)

Gene: UBP5, USP5
Organism: Homo sapiens
Interactions: 150
UniProt ID: P45974

Gene Ontology (top 5):
GO:0002841 - negative regulation of T cell mediated immune response to tumor cell
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507656

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

35

20

Small-scale

0.994

High

507109

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

20

High-throughput

0.839

High

853455

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

3

15

High-throughput

0.827

High

853503

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

16

Small-scale

0.776

High

853454

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

20

High-throughput

0.754

High

853470

PDCD1
Programmed cell death protein 1

1

1

Small-scale

0.747

High

853537

PD1L1
Programmed cell death 1 ligand 1

1

11

Small-scale

0.747

High

853495

UBTD2
Ubiquitin domain-containing protein 2

1

0

Small-scale

0.718

High

853450

RD23B
UV excision repair protein RAD23 homolog B

1

20

Small-scale

0.665

High

425366

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.647

High

853515

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

14

High-throughput

0.647

High

853527

SMUF1
E3 ubiquitin-protein ligase SMURF1

3

20

Small-scale

0.646

High

282170

MAF
Transcription factor Maf

3

5

Small-scale

0.640

High

529290

TAU
Microtubule-associated protein tau

2

10

High-throughput

0.628

High

371409

MYC
Myc proto-oncogene protein

2

18

Small-scale

0.624

High

241006

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

853449

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.618

High

853468

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.618

High

853479

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.618

High

853524

TXNIP
Thioredoxin-interacting protein

2

5

Small-scale

0.611

High

853489

SPART
Spartin

2

4

High-throughput

0.606

High

853522

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

20

High-throughput

0.606

High

853535

RN216
E3 ubiquitin-protein ligase RNF216

2

6

High-throughput

0.606

High

328467

CAC1H
Voltage-dependent T-type calcium channel subunit alpha-1H

3

1

Small-scale

0.601

High

853545

RNF11
RING finger protein 11

2

10

Small-scale

0.600

High

131800

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

20

Small-scale

0.595

High

853547

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.595

High

664673

CCND1
G1/S-specific cyclin-D1

2

10

Small-scale

0.584

High

853460

FOXM1
Forkhead box protein M1

2

8

Small-scale

0.584

High

284809

TADA3
Transcriptional adapter 3

1

4

High-throughput

0.582

High

853469

DAZP2
DAZ-associated protein 2

1

1

High-throughput

0.573

High

226723

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

11

Small-scale

0.561

High

853485

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

2

Small-scale

0.561

High

853490

TRIML
Probable E3 ubiquitin-protein ligase TRIML1

1

17

Small-scale

0.561

High

853517

STK33
Serine/threonine-protein kinase 33

1

7

Small-scale

0.561

High

853447

EFTU
Elongation factor Tu, mitochondrial

1

2

Small-scale

0.553

High

159554

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.541

High

853465

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.536

High

853471

TCAL1
Transcription elongation factor A protein-like 1

1

1

High-throughput

0.536

High

853521

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.536

High

853458

CAV1
Caveolin-1

2

1

High-throughput

0.521

High

487060

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.515

High

163547

TPP1
Tripeptidyl-peptidase 1

1

1

High-throughput

0.515

High

853487

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

421680

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

853452

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

853475

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

9

Small-scale

0.501

High

853493

PJA1
E3 ubiquitin-protein ligase Praja-1

1

11

High-throughput

0.501

High

853498

RFFL
E3 ubiquitin-protein ligase rififylin

1

12

High-throughput

0.501

High

853504

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

853518

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

853519

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.501

High

853477

TMM31
Transmembrane protein 31

1

1

High-throughput

0.489

High

853462

TRI26
Tripartite motif-containing protein 26

1

20

High-throughput

0.481

High

853523

TRIM5
Tripartite motif-containing protein 5

1

20

High-throughput

0.481

High

853528

TRI39
E3 ubiquitin-protein ligase TRIM39

1

20

High-throughput

0.481

High

167850

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

11

Small-scale

0.479

High

170001

AURKA
Aurora kinase A

1

17

Small-scale

0.479

High

216888

KLF4
Krueppel-like factor 4

1

14

Small-scale

0.479

High

221785

SNAI2
Zinc finger protein SNAI2

1

13

Small-scale

0.479

High

222798

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

259584

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

279126

ULK1
Serine/threonine-protein kinase ULK1

1

15

Small-scale

0.479

High

316365

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

Small-scale

0.479

High

405881

MYCN
N-myc proto-oncogene protein

1

17

Small-scale

0.479

High

413366

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

484979

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

Small-scale

0.479

High

519824

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

567289

TCTP
Translationally-controlled tumor protein

1

2

High-throughput

0.479

High

580919

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

606387

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

647497

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.479

High

648333

USF1
Upstream stimulatory factor 1

1

18

Small-scale

0.479

High

674961

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.479

High

681287

PSA3
Proteasome subunit alpha type-3

1

3

Small-scale

0.479

High

713930

PML
Protein PML

1

20

High-throughput

0.479

High

731054

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

764519

CTNB1
Catenin beta-1

1

17

Small-scale

0.479

High

853448

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.479

High

853453

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

853456

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

853457

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

853461

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

853463

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

853464

CUL3
Cullin-3

1

10

High-throughput

0.479

High

853466

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.479

High

853467

CUL7
Cullin-7

1

3

High-throughput

0.479

High

853472

ELAV1
ELAV-like protein 1

1

4

Small-scale

0.479

High

853474

E2F4
Transcription factor E2F4

1

5

High-throughput

0.479

High

853478

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

853482

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

853484

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

853488

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.479

High

853492

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

853494

DUS19
Dual specificity protein phosphatase 19

1

6

High-throughput

0.479

High

853499

TOPB1
DNA topoisomerase 2-binding protein 1

1

9

High-throughput

0.479

High

853500

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

853501

HDAC2
Histone deacetylase 2

1

11

Small-scale

0.479

High

853502

CSN5
COP9 signalosome complex subunit 5

1

7

High-throughput

0.479

High

853506

OTUL
Ubiquitin thioesterase otulin

1

2

Small-scale

0.479

High

853507

ARMC5
Armadillo repeat-containing protein 5

1

16

High-throughput

0.479

High

853508

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

2

Small-scale

0.479

High

853509

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

High-throughput

0.479

High

853510

SNX27
Sorting nexin-27

1

8

High-throughput

0.479

High

853514

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

5

Small-scale

0.479

High

853525

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

853529

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

853530

METL5
rRNA N(6)-adenosine-methyltransferase METTL5

1

2

Small-scale

0.479

High

853531

DUS22
Dual specificity protein phosphatase 22

1

6

High-throughput

0.479

High

853532

HELLS
Lymphoid-specific helicase

1

16

Small-scale

0.479

High

853533

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

Small-scale

0.479

High

853536

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

853539

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

853540

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

Small-scale

0.479

High

853541

SRRM2
Serine/arginine repetitive matrix protein 2

1

13

High-throughput

0.479

High

853548

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

11

Small-scale

0.479

High

853549

MAFB
Transcription factor MafB

1

13

Small-scale

0.479

High

853511

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

853520

OSBL8
Oxysterol-binding protein-related protein 8

1

0

Small-scale

0.458

High

853546

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

572743

PA2GA
Phospholipase A2, membrane associated

1

4

Small-scale

0.457

High

853459

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.457

High

853451

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

853476

KLH22
Kelch-like protein 22

1

6

High-throughput

0.445

High

853480

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

853513

CEP63
Centrosomal protein of 63 kDa

1

10

High-throughput

0.445

High

853542

GAB2
GRB2-associated-binding protein 2

1

13

High-throughput

0.445

High

105519

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

130029

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.437

High

217937

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

353080

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

411538

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.437

High

718682

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

1

Small-scale

0.437

High

767625

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

853481

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

853486

RETR3
Reticulophagy regulator 3

1

3

Small-scale

0.437

High

853496

DEP1B
DEP domain-containing protein 1B

1

4

Small-scale

0.437

High

853516

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

1

1

Small-scale

0.437

High

853526

RETR1
Reticulophagy regulator 1

1

3

Small-scale

0.437

High

853534

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

10

High-throughput

0.437

High

853538

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

2

High-throughput

0.437

High

853473

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

409303

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.407

High

853491

MFSD9
Major facilitator superfamily domain-containing protein 9

1

4

High-throughput

0.407

High

853512

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.407

High

853543

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

853497

TM239
Transmembrane protein 239

3

0

High-throughput

0.352

High

853544

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

853483

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.232

Low

853505

S35B4
Nucleotide sugar transporter SLC35B4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025