HitPredict

Interactor 1: DAB1 (O75553)
Disabled homolog 1
Gene: DAB1

Interactor 2: LRP8 (Q14114)
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
Gene: LRP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	10827199, 10827173, 16481437
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0021517 - ventral spinal cord development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 588 Hs			1 963
+	Hs
		269133 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		VLDLR_HUMAN (5-286): 1.44e-33: 141: 23.49
+	Mm
		956222 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		VLDLR_MOUSE (5-232): 7.68e-31: 132: 24.61
+	Mm
		956234 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LRP8_MOUSE (4-333): 1.96e-29: 128: 27.04
+	Mm
		729617 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LDLR_MOUSE (6-232): 2.8e-26: 118: 21.62
+	Mm
		69879 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		B1AXJ3_MOUSE (5-230): 2.86e-23: 108: 17.30
+	Hs
		269134 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		LRP2_HUMAN (195-464): 3.85e-10: 66.4: 16.03
+	Mm
		956233 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LRP1_MOUSE (690-894): 6.6e-10: 65.6: 11.16
+	Mm
		57553 DAB1_MOUSE (1-588): 3.86e-74: 249: 91.50		LRP2_MOUSE (195-462): 9.58e-10: 65.3: 17.36
+	Hs
		269114 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		LDLR_HUMAN (683-895): 4.15e-09: 62.6: 10.65
+	Hs
		269141 DAB1_HUMAN (1-588): 2.31e-74: 250: 100.00		LRP1_HUMAN (5-257): 6.13e-09: 62.6: 13.53
+	Hs
		992719 GULP1_HUMAN (17-293): 2.72e-60: 204: 21.43		LRP1_HUMAN (5-257): 6.13e-09: 62.6: 13.53
+	Hs
		957621 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		LRP2_HUMAN (195-464): 3.85e-10: 66.4: 16.03
+	Hs
		957612 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		LRP2_HUMAN (195-464): 3.85e-10: 66.4: 16.03
+	Rn
		292326 DAB2_RAT (8-587): 1.42e-43: 168: 22.92		LRP2_RAT (195-462): 4.71e-10: 66: 18.06
+	Hs
		992682 ANS1B_HUMAN (9-229): 2.08e-44: 171: 17.70		LRP1_HUMAN (5-257): 6.13e-09: 62.6: 13.53
+	Mm
		57554 DAB2_MOUSE (8-587): 1.14e-43: 168: 23.51		LRP2_MOUSE (195-462): 9.58e-10: 65.3: 17.36
+	Hs
		351073 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		LDLR_HUMAN (683-895): 4.15e-09: 62.6: 10.65
+	Hs
		957165 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		LRP2_HUMAN (195-464): 3.85e-10: 66.4: 16.03
+	Hs
		270287 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		LRP6_HUMAN (253-435): 5.25e-09: 62.6: 16.04
+	Hs
		351065 DAB2_HUMAN (8-587): 2.74e-41: 161: 23.98		LDLR_HUMAN (683-895): 4.15e-09: 62.6: 10.65