Interactor 1: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6
Interactor 2: SOST (Q9BQB4)
Sclerostin
Gene: SOST
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.86 | 1.00 | 0.927 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 33961781, 15908424, 21944579, 21471202 |
| Identification Methods | affinity chromatography technology, bio-layer interferometry, x-ray crystallography, tandem affinity purification, anti tag coimmunoprecipitation, pull down |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ldl_recept_b~Sclerostin |
| Common GO terms | GO:0005576 - extracellular region GO:0045893 - positive regulation of DNA-templated transcription GO:0060070 - canonical Wnt signaling pathway |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
