HitPredict

Interactor 1: KS6A5 (O75582)
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Gene: RPS6KA5

Interactor 2: CSK2B (P67870)
Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)
Gene: CSNK2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	32707033, 33961781, 21988832
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CK_II_beta~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 215
+	Hs
		272858 KS6A4_HUMAN (18-786): 0: 727: 59.38		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931650 KS6A1_HUMAN (4-752): 0: 714: 40.27		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		850634 KS6A3_HUMAN (366-776): 2.03e-107: 347: 23.47		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931649 KS6A2_HUMAN (423-760): 1.49e-107: 347: 25.78		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Dm
		437155 Q9VR61_DROME (418-795): 4.18e-103: 340: 23.92		CSK2B_DROME (1-215): 1.94e-134: 378: 88.37
+	Hs
		616695 KS6B1_HUMAN (393-797): 2.27e-94: 306: 22.92		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		931918 KS6B2_HUMAN (430-784): 4.96e-94: 304: 23.44		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00
+	Hs
		783974 KPCI_HUMAN (401-676): 1.59e-25: 114: 27.59		CSK2B_HUMAN (1-215): 2.27e-138: 387: 100.00