Protein: SMU1
WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]

Gene: SMU1
Organism: Homo sapiens
Interactions: 190
UniProt ID: Q2TAY7

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1095125

RED
Protein Red

9

5

Small-scale

0.975

High

1180268

CERT
Ceramide transfer protein

2

3

High-throughput

0.783

High

1138269

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

5

High-throughput

0.754

High

1180225

PRP8
Pre-mRNA-processing-splicing factor 8

2

3

High-throughput

0.754

High

1162943

H2B2E
Histone H2B type 2-E

1

7

Small-scale

0.724

High

321557

PRP6
Pre-mRNA-processing factor 6

1

13

High-throughput

0.691

High

1180243

MR1L1
MORF4 family-associated protein 1-like 1

5

2

High-throughput

0.661

High

335854

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

3

2

High-throughput

0.650

High

1180220

SMU1
WD40 repeat-containing protein SMU1

1

18

Small-scale

0.647

High

168541

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

11

High-throughput

0.618

High

289563

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

16

High-throughput

0.618

High

315648

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

532624

CH60
60 kDa heat shock protein, mitochondrial

1

12

High-throughput

0.618

High

673887

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

899407

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.618

High

957086

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

8

High-throughput

0.618

High

970596

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

15

High-throughput

0.618

High

979749

H4
Histone H4

1

8

High-throughput

0.618

High

992779

RACK1
Small ribosomal subunit protein RACK1

1

19

High-throughput

0.618

High

995625

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.618

High

998379

H31
Histone H3.1

1

11

High-throughput

0.618

High

1007705

RAE1L
mRNA export factor RAE1

1

19

High-throughput

0.618

High

1131042

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

15

Small-scale

0.618

High

1157737

DDB1
DNA damage-binding protein 1

1

14

Small-scale

0.618

High

1180228

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

1180229

DHX30
ATP-dependent RNA helicase DHX30

1

12

High-throughput

0.618

High

1180240

FBXW7
F-box/WD repeat-containing protein 7

1

16

Small-scale

0.618

High

1180258

ANLN
Anillin

1

8

High-throughput

0.618

High

1126925

RBM39
RNA-binding protein 39

2

11

High-throughput

0.611

High

225011

TLX3
T-cell leukemia homeobox protein 3

2

13

High-throughput

0.606

High

1180269

MOFA1
MORF4 family-associated protein 1

2

2

High-throughput

0.606

High

935522

MFAP1
Microfibrillar-associated protein 1

2

2

Small-scale

0.600

High

241846

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.584

High

272229

OBSL1
Obscurin-like protein 1

2

9

Small-scale

0.584

High

372177

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

1134930

CUL7
Cullin-7

2

4

Small-scale

0.584

High

1161466

IF16
Gamma-interferon-inducible protein 16

2

7

High-throughput

0.584

High

396228

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

157447

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.553

High

285944

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.536

High

478071

SNRPA
U1 small nuclear ribonucleoprotein A

1

8

High-throughput

0.536

High

480161

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.536

High

529903

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.536

High

574295

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

662585

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

11

High-throughput

0.536

High

791429

SYUA
Alpha-synuclein

1

4

High-throughput

0.536

High

973935

RUXF
Small nuclear ribonucleoprotein F

1

10

High-throughput

0.536

High

987676

GRB2
Growth factor receptor-bound protein 2

1

8

High-throughput

0.536

High

1113239

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1115226

CUL4B
Cullin-4B

1

20

Small-scale

0.536

High

1149077

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.536

High

1180236

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.536

High

1180242

ARRD3
Arrestin domain-containing protein 3

1

6

High-throughput

0.536

High

1180248

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

344544

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

6

High-throughput

0.508

High

994572

YBOX1
Y-box-binding protein 1

1

2

High-throughput

0.508

High

1180267

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

12

High-throughput

0.508

High

508064

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

123717

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.479

High

129138

MEN1
Menin

1

5

High-throughput

0.479

High

134760

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.479

High

144268

ACACB
Acetyl-CoA carboxylase 2

1

12

High-throughput

0.479

High

172877

XPO1
Exportin-1

1

12

High-throughput

0.479

High

223089

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

227171

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

13

Small-scale

0.479

High

227579

SPOP
Speckle-type POZ protein

1

10

High-throughput

0.479

High

247940

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

260036

BRD4
Bromodomain-containing protein 4

1

18

High-throughput

0.479

High

272675

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

15

Small-scale

0.479

High

319808

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

321096

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.479

High

325864

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

Small-scale

0.479

High

331019

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

376845

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

4

High-throughput

0.479

High

400917

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

405294

OAT
Ornithine aminotransferase, mitochondrial

1

2

High-throughput

0.479

High

406236

MYCN
N-myc proto-oncogene protein

1

18

High-throughput

0.479

High

472782

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

480810

LEG1
Galectin-1

1

6

High-throughput

0.479

High

484555

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

520100

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

528264

THIO
Thioredoxin

1

8

High-throughput

0.479

High

551071

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

552262

ADT3
ADP/ATP translocase 3

1

7

High-throughput

0.479

High

587679

DESP
Desmoplakin

1

16

High-throughput

0.479

High

588831

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

637544

FLNA
Filamin-A

1

14

High-throughput

0.479

High

651813

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.479

High

664758

CCND1
G1/S-specific cyclin-D1

1

5

Small-scale

0.479

High

668612

APC
Adenomatous polyposis coli protein

1

15

Small-scale

0.479

High

695604

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

697552

PYR1
Multifunctional protein CAD

1

4

High-throughput

0.479

High

716565

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

6

High-throughput

0.479

High

722717

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

3

High-throughput

0.479

High

729291

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

18

High-throughput

0.479

High

731348

STIP1
Stress-induced-phosphoprotein 1

1

16

High-throughput

0.479

High

732328

PRDX2
Peroxiredoxin-2

1

6

High-throughput

0.479

High

749044

RL9
Large ribosomal subunit protein uL6

1

6

High-throughput

0.479

High

756223

MCM7
DNA replication licensing factor MCM7

1

6

High-throughput

0.479

High

765574

BMI1
Polycomb complex protein BMI-1

1

17

High-throughput

0.479

High

766597

PHB1
Prohibitin 1

1

7

High-throughput

0.479

High

768331

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

775124

FUS
RNA-binding protein FUS

1

15

High-throughput

0.479

High

810134

RL3
Large ribosomal subunit protein uL3

1

7

High-throughput

0.479

High

858942

RL27A
Large ribosomal subunit protein uL15

1

6

High-throughput

0.479

High

862189

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.479

High

904790

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

935882

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

5

High-throughput

0.479

High

937770

FOXA1
Hepatocyte nuclear factor 3-alpha

1

11

High-throughput

0.479

High

955835

DEST
Destrin

1

3

High-throughput

0.479

High

972432

RS14
Small ribosomal subunit protein uS11

1

6

High-throughput

0.479

High

973458

RS11
Small ribosomal subunit protein uS17

1

5

High-throughput

0.479

High

977263

RS4X
Small ribosomal subunit protein eS4, X isoform

1

4

High-throughput

0.479

High

985687

RL11
Large ribosomal subunit protein uL5

1

4

High-throughput

0.479

High

991034

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.479

High

1067408

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.479

High

1092143

NFX1
Transcriptional repressor NF-X1

1

9

High-throughput

0.479

High

1099959

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.479

High

1100605

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.479

High

1100810

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.479

High

1106927

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1107779

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

1112406

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

3

High-throughput

0.479

High

1140356

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1156729

E2F4
Transcription factor E2F4

1

4

High-throughput

0.479

High

1157700

CSRP2
Cysteine and glycine-rich protein 2

1

3

High-throughput

0.479

High

1163913

UPP1
Uridine phosphorylase 1

1

1

High-throughput

0.479

High

1180230

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

Small-scale

0.479

High

1180231

ZCH18
Zinc finger CCCH domain-containing protein 18

1

17

High-throughput

0.479

High

1180232

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

High-throughput

0.479

High

1180233

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

1180235

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

1180237

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1180238

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1180239

RBP56
TATA-binding protein-associated factor 2N

1

11

High-throughput

0.479

High

1180244

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

1180246

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1180249

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.479

High

1180250

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

1180251

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

1180252

TBB2B
Tubulin beta-2B chain

1

20

High-throughput

0.479

High

1180253

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

1180255

CCDC8
Coiled-coil domain-containing protein 8

1

2

Small-scale

0.479

High

1180259

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1180260

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

1180262

DJC17
DnaJ homolog subfamily C member 17

1

14

High-throughput

0.479

High

1180263

PEF1
Peflin

1

1

High-throughput

0.479

High

1180264

DIC
Mitochondrial dicarboxylate carrier

1

11

High-throughput

0.479

High

1180265

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1180266

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

1180270

MTCH2
Mitochondrial carrier homolog 2

1

10

High-throughput

0.479

High

890964

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.470

High

1083468

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

1180241

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1180245

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.458

High

429986

JUN
Transcription factor Jun

1

14

High-throughput

0.445

High

664875

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

1

High-throughput

0.445

High

911608

NCBP2
Nuclear cap-binding protein subunit 2

1

9

High-throughput

0.445

High

1119157

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

6

High-throughput

0.445

High

1150726

SF01
Splicing factor 1

1

4

High-throughput

0.445

High

1180222

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

1180223

ODFP2
Outer dense fiber protein 2

1

11

High-throughput

0.445

High

1180247

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

209574

SERA
D-3-phosphoglycerate dehydrogenase

1

8

High-throughput

0.437

High

350599

TXD12
Thioredoxin domain-containing protein 12

1

3

High-throughput

0.437

High

418170

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

425913

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

20

High-throughput

0.437

High

680376

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

High-throughput

0.437

High

728778

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

3

High-throughput

0.437

High

733939

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.437

High

882694

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.437

High

895571

SERPH
Serpin H1

1

4

High-throughput

0.437

High

932879

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

7

High-throughput

0.437

High

1142287

PDIA6
Protein disulfide-isomerase A6

1

11

High-throughput

0.437

High

1156503

CCDC6
Coiled-coil domain-containing protein 6

1

13

High-throughput

0.437

High

1180226

RICTR
Rapamycin-insensitive companion of mTOR

1

4

High-throughput

0.437

High

1180227

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.437

High

1180234

TXND5
Thioredoxin domain-containing protein 5

1

11

High-throughput

0.437

High

1180254

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1180257

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

20

High-throughput

0.437

High

1180261

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

7

High-throughput

0.437

High

886917

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.408

High

1180224

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

66501

RASFA
Ras association domain-containing protein 10

2

0

High-throughput

0.316

High

1180221

MSS51
Putative protein MSS51 homolog, mitochondrial

2

0

High-throughput

0.316

High

1120446

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

301450

WFS1
Wolframin

1

0

High-throughput

0.268

Low

853104

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

1180256

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025