HitPredict

Interactor 1: DEPD5 (O75140)
GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5)
Gene: DEPDC5

Interactor 2: RRAGA (Q7L523)
Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1)
Gene: RRAGA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	23723238, 25936802, 26051179, 25366275
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DEPDC5_CTD~Gtr1_RagA, Gtr1_RagA~IML1_N
Common GO terms	GO:0005764 - lysosome GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0034198 - cellular response to amino acid starvation GO:0035556 - intracellular signal transduction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1603 Hs			1 313
+	Hs
		271359 DEPD5_HUMAN (1-1603): 0: 2753: 100.00		RRAGB_HUMAN (1-313): 1.72e-169: 476: 90.03
+	Hs
		271374 DEPD5_HUMAN (1-1603): 0: 2753: 100.00		RRAGC_HUMAN (5-235): 1.27e-100: 302: 25.42
+	Hs
		271375 DEPD5_HUMAN (1-1603): 0: 2753: 100.00		RRAGD_HUMAN (3-235): 4.99e-100: 301: 24.79
+	Sc
		866241 IML1_YEAST (1204-1514): 4.05e-74: 275: 21.86		RAGAB_YEAST (3-298): 3.1e-121: 352: 50.96