Protein: DEPD5
GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5)

Gene: DEPD5, DEPDC5
Organism: Homo sapiens
Interactions: 40
UniProt ID: O75140

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0010508 - positive regulation of autophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

271364

NPRL2
GATOR1 complex protein NPRL2

9

3

Small-scale

0.972

High

271371

WDR24
GATOR2 complex protein WDR24

4

5

Small-scale

0.886

High

271363

RRAGA
Ras-related GTP-binding protein A

4

4

Small-scale

0.878

High

271374

RRAGC
Ras-related GTP-binding protein C

3

4

Small-scale

0.873

High

271359

RRAGB
Ras-related GTP-binding protein B

2

4

Small-scale

0.799

High

271361

WDR59
GATOR2 complex protein WDR59

2

7

Small-scale

0.754

High

271353

NPRL3
GATOR1 complex protein NPRL3

6

2

Small-scale

0.735

High

271358

SZT2
KICSTOR complex protein SZT2

4

0

Small-scale

0.670

High

271376

MIOS
GATOR2 complex protein MIOS

3

4

Small-scale

0.656

High

271366

ITFG2
KICSTOR complex protein ITFG2

3

0

Small-scale

0.638

High

271369

KICS2
KICSTOR subunit 2

3

0

Small-scale

0.638

High

271379

KPTN
KICSTOR complex protein kaptin

3

0

Small-scale

0.638

High

271356

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

3

0

High-throughput

0.634

High

271375

RRAGD
Ras-related GTP-binding protein D

1

4

Small-scale

0.618

High

271354

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

1

High-throughput

0.606

High

271340

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

0

High-throughput

0.580

High

271347

TCPG
T-complex protein 1 subunit gamma

2

0

High-throughput

0.580

High

271370

MTMR9
Myotubularin-related protein 9

2

0

High-throughput

0.580

High

271357

KLH22
Kelch-like protein 22

1

0

Small-scale

0.554

High

271377

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

1

High-throughput

0.553

High

271352

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.536

High

271342

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.513

High

271365

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

271350

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

271355

CUL3
Cullin-3

1

1

Small-scale

0.479

High

271360

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

271343

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

271344

MCM3
DNA replication licensing factor MCM3

1

0

High-throughput

0.458

High

271349

SESN2
Sestrin-2

1

0

Small-scale

0.458

High

271351

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

271367

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

271378

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.458

High

271346

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.445

High

271348

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

271341

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

271368

ZN414
Zinc finger protein 414

2

0

High-throughput

0.318

High

271362

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.316

High

271373

SYT17
Synaptotagmin-17

2

0

High-throughput

0.316

High

271345

RBTN1
Rhombotin-1

1

0

High-throughput

0.279

Low

271372

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025