HitPredict

Interactor 1: U520 (O75643)
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Gene: SNRNP200

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	29884807, 35271311, 27460707
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2136 Hs			1 526
+	Hs
		272226 U520_HUMAN (1-2136): 0: 1844: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		272106 U520_HUMAN (1-2136): 0: 1844: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		272321 U520_HUMAN (1-2136): 0: 1844: 100.00		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		1232228 ASCC3_HUMAN (56-2134): 0: 1449: 38.34		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Sp
		678721 BRR2_SCHPO (10-2129): 0: 1452: 48.16		PABP_SCHPO (242-381): 4.01e-12: 70.8: 15.71
+	Hs
		516589 ASCC3_HUMAN (56-2134): 0: 1449: 38.34		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Sc
		376698 BRR2_YEAST (4-2127): 0: 1258: 38.75		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49
+	Hs
		571537 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		1204682 DDX42_HUMAN (231-900): 2.59e-103: 357: 13.42		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		1271148 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		786992 MTREX_HUMAN (1287-2037): 2.62e-101: 354: 18.12		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		571333 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		726912 DDX42_HUMAN (231-900): 2.59e-103: 357: 13.42		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		726967 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		726635 MTREX_HUMAN (1287-2037): 2.62e-101: 354: 18.12		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		571409 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		571634 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		967316 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		1271695 DDX17_HUMAN (405-901): 6.31e-105: 356: 13.72		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		571648 DDX5_HUMAN (1241-1718): 1.86e-108: 362: 12.47		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35