HitPredict

Interactor 1: BCAR3 (O75815)
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Gene: BCAR3

Interactor 2: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007165 - signal transduction GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 825 Hs			1 976
+	Hs
		499275 SH2D3_HUMAN (8-825): 0: 686: 39.39		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		433226 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499222 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		433221 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Mm
		404012 FYN_MOUSE (12-349): 2.32e-58: 210: 11.85		PGFRB_MOUSE (14-974): 0: 597: 29.51
+	Hs
		452342 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		452338 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		433274 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		522826 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		522773 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10
+	Hs
		433229 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Hs
		507829 VAV_HUMAN (10-316): 3.02e-58: 215: 16.33		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Hs
		507818 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Mm
		403408 SRC_MOUSE (33-349): 1.78e-60: 215: 14.24		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Mm
		452181 FYN_MOUSE (12-349): 2.32e-58: 210: 11.85		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Hs
		433247 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01
+	Hs
		426975 YES_HUMAN (2-333): 6.77e-61: 217: 13.14		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10
+	Hs
		522825 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04
+	Hs
		426981 SRC_HUMAN (33-349): 1.87e-59: 213: 13.95		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10
+	Hs
		411943 FYN_HUMAN (12-349): 2.18e-58: 210: 11.85		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10