HitPredict

Interactor 1: AP1G2 (O75843)
AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)
Gene: AP1G2

Interactor 2: AP1S2 (P56377)
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)
Gene: AP1S2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.905

Property	Details
Experiments	26496610, 28514442, 9733768, 33961781
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0030121 - AP-1 adaptor complex and 1 others more... GO:0035615 - clathrin adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 785 Hs			1 157
+	Hs
		212611 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S2_HUMAN (1-157): 3.42e-55: 172: 100.00
+	Hs
		212614 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26
+	Hs
		212659 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S3_HUMAN (1-153): 9.56e-49: 155: 71.24
+	Hs
		212662 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23
+	Mm
		612130 AP1G1_MOUSE (1-785): 0: 735: 58.69		AP1M1_MOUSE (2-153): 2.42e-43: 149: 19.23
+	Hs
		212655 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Hs
		276362 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26
+	Hs
		212608 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	Hs
		276385 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1S3_HUMAN (1-153): 9.56e-49: 155: 71.24
+	Hs
		276382 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Hs
		880408 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP1S2_HUMAN (1-157): 3.42e-55: 172: 100.00
+	Rn
		577193 AP2A2_RAT (1-776): 0: 555: 24.97		AP2M1_RAT (1-153): 7.95e-41: 143: 16.23
+	Hs
		903681 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP1S1_HUMAN (1-157): 6.65e-55: 171: 87.26
+	Mm
		567520 AP2A2_MOUSE (1-776): 0: 556: 24.97		AP2S1_MOUSE (1-141): 2.21e-41: 136: 46.10
+	Hs
		302192 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Hs
		302125 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	Ce
		725364 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		AP2M_CAEEL (1-153): 1.22e-41: 145: 17.09
+	Ce
		1090495 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		Q19123_CAEEL (1-141): 7.74e-41: 135: 46.81
+	Sc
		715579 AP1G1_YEAST (6-775): 5.6e-177: 530: 29.43		AP1S1_YEAST (1-148): 5.7e-43: 141: 53.33
+	Hs
		864065 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10