HitPredict

Interactor 1: AP1G2 (O75843)
AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)
Gene: AP1G2

Interactor 2: AP1S3 (Q96PC3)
AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin)
Gene: AP1S3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0000139 - Golgi membrane GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0030121 - AP-1 adaptor complex GO:0035615 - clathrin adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 785 Hs			1 154
+	Hs
		212611 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S2_HUMAN (2-154): 1.83e-54: 170: 71.24
+	Hs
		212614 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S1_HUMAN (1-154): 1.51e-54: 170: 67.53
+	Hs
		212659 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S3_HUMAN (1-154): 1.61e-53: 167: 100.00
+	Hs
		212662 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1M1_HUMAN (3-146): 8.38e-45: 153: 19.44
+	Mm
		612130 AP1G1_MOUSE (1-785): 0: 735: 58.69		AP1M1_MOUSE (3-146): 7.38e-45: 153: 19.44
+	Hs
		212676 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1M2_HUMAN (3-147): 9.28e-43: 148: 17.93
+	Hs
		212608 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2S1_HUMAN (1-142): 2.1e-45: 146: 42.96
+	Hs
		212655 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2M1_HUMAN (1-153): 5.51e-42: 146: 17.50
+	Hs
		276360 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1S2_HUMAN (2-154): 1.83e-54: 170: 71.24
+	Hs
		276362 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1S1_HUMAN (1-154): 1.51e-54: 170: 67.53
+	Hs
		276398 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1M2_HUMAN (3-147): 9.28e-43: 148: 17.93
+	Hs
		276382 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP2M1_HUMAN (1-153): 5.51e-42: 146: 17.50
+	Mm
		567520 AP2A2_MOUSE (1-776): 0: 556: 24.97		AP2S1_MOUSE (1-142): 2.1e-45: 146: 42.96
+	Hs
		880408 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP1S2_HUMAN (2-154): 1.83e-54: 170: 71.24
+	Hs
		302125 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2S1_HUMAN (1-142): 2.1e-45: 146: 42.96
+	Hs
		302192 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2M1_HUMAN (1-153): 5.51e-42: 146: 17.50
+	Ce
		725364 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		AP2M_CAEEL (1-153): 1.56e-43: 150: 18.29
+	Ce
		1090495 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		Q19123_CAEEL (1-142): 3.33e-45: 146: 43.66
+	Sc
		715579 AP1G1_YEAST (6-775): 5.6e-177: 530: 29.43		AP1S1_YEAST (2-152): 8.52e-45: 145: 45.10
+	Hs
		864065 AP2B1_HUMAN (29-737): 3.35e-174: 527: 15.35		AP2S1_HUMAN (1-142): 2.1e-45: 146: 42.96