HitPredict

Interactor 1: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22275353
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031901 - early endosome membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 525 Hs			1 903
+	Hs
		1270607 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125613 STAM1_HUMAN (1-510): 2.25e-111: 343: 54.88		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1294876 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1078893 ITSN1_HUMAN (188-414): 1.91e-46: 176: 22.50		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125533 TM1L2_HUMAN (1-466): 2.13e-88: 282: 17.19		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125035 TOM1_HUMAN (1-444): 1.01e-80: 262: 17.68		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		160143 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		275221 GRAP2_HUMAN (175-256): 5.08e-13: 72: 41.46		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		808171 TM1L2_HUMAN (1-466): 2.13e-88: 282: 17.19		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		241153 TOM1_HUMAN (1-444): 1.01e-80: 262: 17.68		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		125001 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125051 GRAP2_HUMAN (175-256): 5.08e-13: 72: 41.46		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		808298 GGA3_HUMAN (1-510): 1.35e-56: 203: 15.73		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		160160 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		159925 HGS_HUMAN (135-518): 7.87e-15: 79.4: 10.95		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1173029 TM1L2_HUMAN (1-466): 2.13e-88: 282: 17.19		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		241199 TOM1_HUMAN (1-444): 1.01e-80: 262: 17.68		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1045530 SPTN1_HUMAN (103-481): 2.5e-55: 202: 14.59		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Sc
		765278 VPS27_YEAST (1-488): 4.18e-59: 208: 16.02		RSP5_YEAST (16-440): 9.75e-40: 160: 19.07
+	Sc
		753622 HSE1_YEAST (15-449): 6.92e-53: 187: 19.56		RSP5_YEAST (16-440): 9.75e-40: 160: 19.07