Protein: LHX8
LIM/homeobox protein Lhx8 (LIM homeobox protein 8)

Gene: LHX8
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q68G74

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1229355

LDB1
LIM domain-binding protein 1

4

20

High-throughput

0.909

High

1229352

FIGLA
Factor in the germline alpha

3

12

High-throughput

0.858

High

223931

LDB2
LIM domain-binding protein 2

2

20

High-throughput

0.783

High

1229372

SSBP4
Single-stranded DNA-binding protein 4

4

20

High-throughput

0.694

High

944682

KLF3
Krueppel-like factor 3

2

10

High-throughput

0.628

High

965470

LMO4
LIM domain transcription factor LMO4

1

20

High-throughput

0.618

High

1229366

ISL2
Insulin gene enhancer protein ISL-2

1

19

High-throughput

0.618

High

1229379

LHX6
LIM/homeobox protein Lhx6

1

17

High-throughput

0.618

High

186854

FOXN1
Forkhead box protein N1

2

8

High-throughput

0.606

High

208851

ZBT24
Zinc finger and BTB domain-containing protein 24

2

4

High-throughput

0.606

High

583570

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

2

High-throughput

0.606

High

584106

FOSL2
Fos-related antigen 2

2

4

High-throughput

0.606

High

943652

SIK1
Serine/threonine-protein kinase SIK1

2

1

High-throughput

0.606

High

997785

CSK21
Casein kinase II subunit alpha

2

7

High-throughput

0.606

High

1127351

CASL
Enhancer of filamentation 1

2

12

High-throughput

0.606

High

1229354

TBCD1
TBC1 domain family member 1

2

2

High-throughput

0.606

High

1229361

CCHCR
Coiled-coil alpha-helical rod protein 1

2

2

High-throughput

0.606

High

1229363

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.606

High

1229377

ABI2
Abl interactor 2

2

20

High-throughput

0.606

High

1229353

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

4

High-throughput

0.594

High

1229370

SLD5
DNA replication complex GINS protein SLD5

2

0

High-throughput

0.580

High

855646

CRK
Adapter molecule crk

2

20

High-throughput

0.576

High

1229358

NUTM1
NUT family member 1

1

1

High-throughput

0.573

High

211987

EFS
Embryonal Fyn-associated substrate

2

11

High-throughput

0.553

High

1007522

KRT85
Keratin, type II cuticular Hb5

2

4

High-throughput

0.553

High

1229360

BANP
Protein BANP

2

4

High-throughput

0.553

High

1229376

TB22B
TBC1 domain family member 22B

2

2

High-throughput

0.553

High

599296

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

1

High-throughput

0.542

High

1229373

SSBP3
Single-stranded DNA-binding protein 3

1

20

High-throughput

0.536

High

1229359

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.523

High

843657

HD
Huntingtin

1

3

High-throughput

0.515

High

1229367

Q96QL7
ATF6B protein

1

1

High-throughput

0.515

High

1229380

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

216461

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

9

High-throughput

0.508

High

1229381

PYGO1
Pygopus homolog 1

1

20

High-throughput

0.489

High

181125

AXIN1
Axin-1

1

2

High-throughput

0.481

High

1229368

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

8

High-throughput

0.481

High

161479

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174358

ZN609
Zinc finger protein 609

1

12

High-throughput

0.479

High

766629

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

903182

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

11

High-throughput

0.479

High

1010758

SSBP2
Single-stranded DNA-binding protein 2

1

20

High-throughput

0.479

High

1024074

TFAM
Transcription factor A, mitochondrial

1

17

High-throughput

0.479

High

1047836

TLE1
Transducin-like enhancer protein 1

1

11

High-throughput

0.479

High

1228240

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1229356

PB1
Protein polybromo-1

1

15

High-throughput

0.479

High

1229362

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1229364

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

1229365

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

1229371

PCGF1
Polycomb group RING finger protein 1

1

13

High-throughput

0.479

High

1229375

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

109421

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

231714

PEX1
Peroxisomal ATPase PEX1

1

1

High-throughput

0.470

High

245980

KIF1B
Kinesin-like protein KIF1B

1

3

High-throughput

0.470

High

301480

WFS1
Wolframin

1

1

High-throughput

0.470

High

650226

FGFR3
Fibroblast growth factor receptor 3

1

7

High-throughput

0.470

High

705405

GRN
Progranulin

1

1

High-throughput

0.470

High

1133882

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

1

High-throughput

0.470

High

1199312

GLE1
mRNA export factor GLE1

1

1

High-throughput

0.470

High

1229357

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

1229378

UBQL1
Ubiquilin-1

1

3

High-throughput

0.470

High

3348

A0A0S2Z4M1
Axin-1

1

2

High-throughput

0.457

High

139007

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.437

High

1092564

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.437

High

1229369

PYGO2
Pygopus homolog 2

1

11

High-throughput

0.437

High

1229374

GRPE1
GrpE protein homolog 1, mitochondrial

1

1

High-throughput

0.437

High

876014

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025