HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25948554, 22412018
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031507 - heterochromatin formation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 664
+	Hs
		277554 H2AY_HUMAN (1-369): 6.52e-165: 467: 100.00		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45
+	Hs
		634673 H2AW_HUMAN (1-368): 1.42e-145: 418: 66.04		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45
+	Hs
		385421 H2AX_HUMAN (1-142): 1.08e-65: 206: 60.69		LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00
+	Hs
		385928 H2A2B_HUMAN (1-125): 5.81e-65: 204: 64.06		LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00
+	Hs
		385357 H2A1B_HUMAN (1-126): 1.28e-64: 203: 62.02		LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00
+	Hs
		634597 H2A1J_HUMAN (1-125): 5.27e-65: 204: 62.50		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45
+	Hs
		634464 H2A2C_HUMAN (1-125): 9.27e-64: 201: 63.28		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45
+	Hs
		418791 H2A1B_HUMAN (1-126): 1.28e-64: 203: 62.02		VIME_HUMAN (27-389): 3.96e-31: 129: 28.93