Protein: H2AW
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)

Gene: H2AW, MACROH2A2
Organism: Homo sapiens
Interactions: 241
UniProt ID: Q9P0M6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0000976 - transcription cis-regulatory region binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998889

H31
Histone H3.1

4

20

High-throughput

0.873

High

1065472

SSRP1
FACT complex subunit SSRP1

3

20

High-throughput

0.871

High

277837

H2AY
Core histone macro-H2A.1

3

19

High-throughput

0.861

High

1381875

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.861

High

981148

H2B1C
Histone H2B type 1-C/E/F/G/I

3

20

High-throughput

0.827

High

888360

MCM2
DNA replication licensing factor MCM2

2

20

High-throughput

0.811

High

1041863

CENPC
Centromere protein C

2

12

High-throughput

0.811

High

1193396

GLYR1
Cytokine-like nuclear factor N-PAC

2

11

High-throughput

0.811

High

1228607

SPT2
Protein SPT2 homolog

2

5

High-throughput

0.811

High

1307332

H2A2B
Histone H2A type 2-B

2

19

High-throughput

0.811

High

1399504

IPO9
Importin-9

2

10

High-throughput

0.811

High

1453907

SP16H
FACT complex subunit SPT16

2

12

High-throughput

0.811

High

502155

H2AZ
Histone H2A.Z

2

20

High-throughput

0.789

High

1017261

H33
Histone H3.3

2

20

High-throughput

0.789

High

373358

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.754

High

1453897

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

20

High-throughput

0.737

High

1216248

H37
Histone H3-7

2

20

High-throughput

0.712

High

449800

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.691

High

455881

H10
Histone H1.0

1

7

High-throughput

0.691

High

1163251

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1278821

HDGR2
Hepatoma-derived growth factor-related protein 2

1

20

High-throughput

0.691

High

1323994

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.691

High

1450940

NLE1
Notchless protein homolog 1

1

9

High-throughput

0.691

High

1309440

APLF
Aprataxin and PNK-like factor

3

6

High-throughput

0.667

High

1453909

U3KQK0
Histone H2B

1

20

High-throughput

0.665

High

1155842

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.646

High

1368162

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.646

High

1450780

KTU
Protein kintoun

3

0

High-throughput

0.638

High

1453892

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

187201

PPM1G
Protein phosphatase 1G

2

13

High-throughput

0.628

High

208407

RRP8
Ribosomal RNA-processing protein 8

2

1

High-throughput

0.628

High

251665

CCNT1
Cyclin-T1

2

3

High-throughput

0.628

High

252267

CCNT2
Cyclin-T2

2

3

High-throughput

0.628

High

295044

ZN189
Zinc finger protein 189

2

1

High-throughput

0.628

High

325142

HEXI1
Protein HEXIM1

2

13

High-throughput

0.628

High

429031

RLA0
Large ribosomal subunit protein uL10

2

7

High-throughput

0.628

High

841486

RBM34
RNA-binding protein 34

2

11

High-throughput

0.628

High

975998

RL7A
Large ribosomal subunit protein eL8

2

6

High-throughput

0.628

High

1032880

XPC
DNA repair protein complementing XP-C cells

2

8

High-throughput

0.628

High

1043769

CEBPZ
CCAAT/enhancer-binding protein zeta

2

1

High-throughput

0.628

High

1089275

TRI26
Tripartite motif-containing protein 26

2

6

High-throughput

0.628

High

1109228

PRP4K
Serine/threonine-protein kinase PRP4 homolog

2

20

High-throughput

0.628

High

1130870

RRP5
Protein RRP5 homolog

2

5

High-throughput

0.628

High

1130988

BMS1
Ribosome biogenesis protein BMS1 homolog

2

4

High-throughput

0.628

High

1140042

RRS1
Ribosome biogenesis regulatory protein homolog

2

2

High-throughput

0.628

High

1148177

PUM3
Pumilio homolog 3

2

2

High-throughput

0.628

High

1219060

RSBN1
Lysine-specific demethylase 9

2

2

High-throughput

0.628

High

1234793

ZN770
Zinc finger protein 770

2

2

High-throughput

0.628

High

1253829

MMS22
Protein MMS22-like

2

5

High-throughput

0.628

High

1331053

DDX51
ATP-dependent RNA helicase DDX51

2

11

High-throughput

0.628

High

1333150

ZFP62
Zinc finger protein 62 homolog

2

1

High-throughput

0.628

High

1356046

NOC3L
Nucleolar complex protein 3 homolog

2

6

High-throughput

0.628

High

1361399

BBX
HMG box transcription factor BBX

2

4

High-throughput

0.628

High

1392829

TONSL
Tonsoku-like protein

2

17

High-throughput

0.628

High

1400974

PURB
Transcriptional regulator protein Pur-beta

2

5

High-throughput

0.628

High

1410760

MBB1A
Myb-binding protein 1A

2

3

High-throughput

0.628

High

1428485

REXO4
RNA exonuclease 4

2

1

High-throughput

0.628

High

1435613

RPF2
Ribosome production factor 2 homolog

2

2

High-throughput

0.628

High

1438131

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

3

High-throughput

0.628

High

1451993

TEX10
Testis-expressed protein 10

2

2

High-throughput

0.628

High

1452146

CARF
CDKN2A-interacting protein

2

2

High-throughput

0.628

High

1453890

PARP2
Poly [ADP-ribose] polymerase 2

2

19

High-throughput

0.628

High

1453906

RBM19
Probable RNA-binding protein 19

2

20

High-throughput

0.628

High

1408001

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.621

High

180948

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.618

High

257005

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

285500

EED
Polycomb protein EED

1

17

High-throughput

0.618

High

406748

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.618

High

419244

H2A1B
Histone H2A type 1-B/E

1

19

High-throughput

0.618

High

502575

H2A1
Histone H2A type 1

1

19

High-throughput

0.618

High

714473

PML
Protein PML

1

6

High-throughput

0.618

High

908471

HDGF
Hepatoma-derived growth factor

1

17

High-throughput

0.618

High

980456

H4
Histone H4

1

17

High-throughput

0.618

High

987249

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.618

High

1133015

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

1239486

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1258962

H32
Histone H3.2

1

20

High-throughput

0.618

High

1330961

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.618

High

1436812

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.618

High

1449233

RAD18
E3 ubiquitin-protein ligase RAD18

1

6

High-throughput

0.618

High

1453889

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

1137556

SUZ12
Polycomb protein SUZ12

2

6

Small-scale

0.611

High

1453899

RL26L
Ribosomal protein uL24-like

2

9

High-throughput

0.611

High

1272002

CENPQ
Centromere protein Q

2

0

High-throughput

0.602

High

1275510

TRM1L
tRNA

2

0

High-throughput

0.602

High

404493

GCR
Glucocorticoid receptor

2

15

Small-scale

0.584

High

674356

BRD2
Bromodomain-containing protein 2

2

20

High-throughput

0.584

High

1141339

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

1403664

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

20

High-throughput

0.575

High

1453893

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

High-throughput

0.575

High

244416

NPA1P
Nucleolar pre-ribosomal-associated protein 1

2

1

High-throughput

0.574

High

1231678

RL7L
Ribosomal protein uL30-like

2

2

High-throughput

0.574

High

1351489

BRX1
Ribosome biogenesis protein BRX1 homolog

2

12

High-throughput

0.574

High

1407722

EBP2
Probable rRNA-processing protein EBP2

2

4

High-throughput

0.574

High

1417578

MAK16
Protein MAK16 homolog

2

2

High-throughput

0.574

High

1428567

DDX24
ATP-dependent RNA helicase DDX24

2

9

High-throughput

0.574

High

1437296

RPF1
Ribosome production factor 1

2

6

High-throughput

0.574

High

1445878

ZCC17
Zinc finger CCHC domain-containing protein 17

2

4

High-throughput

0.574

High

1450728

DDX18
ATP-dependent RNA helicase DDX18

2

11

High-throughput

0.574

High

1451020

RBM28
RNA-binding protein 28

2

14

High-throughput

0.574

High

1452284

TBA8
Tubulin alpha-8 chain

2

3

High-throughput

0.574

High

1453887

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

2

19

High-throughput

0.571

High

1331795

F133A
Protein FAM133A

2

1

High-throughput

0.553

High

1430220

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

9

High-throughput

0.541

High

133138

FOXE1
Forkhead box protein E1

1

6

High-throughput

0.536

High

137490

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

14

High-throughput

0.536

High

257988

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

4

High-throughput

0.536

High

298631

RAD17
Cell cycle checkpoint protein RAD17

1

12

High-throughput

0.536

High

426587

HMGN2
Non-histone chromosomal protein HMG-17

1

14

High-throughput

0.536

High

428534

RLA2
Large ribosomal subunit protein P2

1

2

High-throughput

0.536

High

447525

NPM
Nucleophosmin

1

9

High-throughput

0.536

High

481399

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

487835

PARP1
Poly [ADP-ribose] polymerase 1

1

20

High-throughput

0.536

High

530483

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.536

High

542258

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

542677

TOP2A
DNA topoisomerase 2-alpha

1

9

High-throughput

0.536

High

600210

ZNF22
Zinc finger protein 22

1

4

High-throughput

0.536

High

601887

HMGA1
High mobility group protein HMG-I/HMG-Y

1

8

High-throughput

0.536

High

634673

LMNB1
Lamin-B1

1

8

High-throughput

0.536

High

755807

MCM4
DNA replication licensing factor MCM4

1

20

High-throughput

0.536

High

770067

RFC1
Replication factor C subunit 1

1

9

High-throughput

0.536

High

785500

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.536

High

788244

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

810434

RL3
Large ribosomal subunit protein uL3

1

6

High-throughput

0.536

High

906940

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.536

High

960925

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

961871

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.536

High

973330

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.536

High

986257

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.536

High

1006765

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.536

High

1013115

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

2

High-throughput

0.536

High

1097123

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

4

High-throughput

0.536

High

1119643

KGP1
cGMP-dependent protein kinase 1

1

19

High-throughput

0.536

High

1134753

NUMA1
Nuclear mitotic apparatus protein 1

1

17

High-throughput

0.536

High

1150264

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.536

High

1194428

LARP7
La-related protein 7

1

20

High-throughput

0.536

High

1235551

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.536

High

1241421

MED27
Mediator of RNA polymerase II transcription subunit 27

1

4

High-throughput

0.536

High

1270665

COX15
Heme A synthase COX15

1

2

High-throughput

0.536

High

1328351

ZC3H8
Zinc finger CCCH domain-containing protein 8

1

6

High-throughput

0.536

High

1408487

VRK1
Serine/threonine-protein kinase VRK1

1

5

High-throughput

0.536

High

1419715

GTPB4
GTP-binding protein 4

1

2

High-throughput

0.536

High

1431067

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

4

High-throughput

0.536

High

1436294

DDX31
ATP-dependent DNA helicase DDX31

1

8

High-throughput

0.536

High

1446772

SSF1
Suppressor of SWI4 1 homolog

1

2

High-throughput

0.536

High

1447827

DDX21
Nucleolar RNA helicase 2

1

10

High-throughput

0.536

High

1453900

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

2

High-throughput

0.536

High

1453901

RUVB2
RuvB-like 2

1

12

High-throughput

0.536

High

1453905

NOC2L
Nucleolar complex protein 2 homolog

1

4

High-throughput

0.536

High

391506

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

855240

NOP2
28S rRNA

1

0

High-throughput

0.513

High

1307395

RIOX2
Ribosomal oxygenase 2

1

0

High-throughput

0.513

High

338199

NSA2
Ribosome biogenesis protein NSA2 homolog

1

1

High-throughput

0.489

High

1240505

DHX57
Putative ATP-dependent RNA helicase DHX57

1

16

High-throughput

0.489

High

1256750

NKAP1
Uncharacterized protein NKAPD1

1

2

High-throughput

0.489

High

1335276

NECP1
Adaptin ear-binding coat-associated protein 1

1

3

High-throughput

0.489

High

1411821

LLPH
Protein LLP homolog

1

1

High-throughput

0.489

High

1453894

MRT4
mRNA turnover protein 4 homolog

1

7

High-throughput

0.489

High

1453903

KLH20
Kelch-like protein 20

1

3

High-throughput

0.489

High

223391

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

248119

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

260557

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

331376

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

446069

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

520639

RARA
Retinoic acid receptor alpha

1

12

Small-scale

0.479

High

558455

XRCC6
X-ray repair cross-complementing protein 6

1

14

High-throughput

0.479

High

589906

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

615600

NELFE
Negative elongation factor E

1

2

High-throughput

0.479

High

696724

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

769382

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

791789

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

831560

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

905223

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.479

High

960282

RL26
Large ribosomal subunit protein uL24

1

9

High-throughput

0.479

High

1035961

KIF23
Kinesin-like protein KIF23

1

16

High-throughput

0.479

High

1127212

RBM39
RNA-binding protein 39

1

13

High-throughput

0.479

High

1130207

SMC1A
Structural maintenance of chromosomes protein 1A

1

5

High-throughput

0.479

High

1140962

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1161723

IF16
Gamma-interferon-inducible protein 16

1

6

High-throughput

0.479

High

1201259

ESCO2
N-acetyltransferase ESCO2

1

3

Small-scale

0.479

High

1328983

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

1346964

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.479

High

1349454

PIWL2
Piwi-like protein 2

1

3

High-throughput

0.479

High

1433097

CHM4B
Charged multivesicular body protein 4b

1

9

High-throughput

0.479

High

1436521

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

1450907

RNF12
E3 ubiquitin-protein ligase RLIM

1

8

High-throughput

0.479

High

1453908

MRCKB
Serine/threonine-protein kinase MRCK beta

1

17

High-throughput

0.479

High

851686

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

975515

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.458

High

1158578

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1057010

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.457

High

65283

ZN316
Zinc finger protein 316

1

2

High-throughput

0.445

High

175796

SR140
U2 snRNP-associated SURP motif-containing protein

1

5

High-throughput

0.445

High

298107

SPF27
Pre-mRNA-splicing factor SPF27

1

1

High-throughput

0.445

High

430449

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

658445

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.445

High

809892

RS19
Small ribosomal subunit protein eS19

1

6

High-throughput

0.445

High

860991

RS10
Small ribosomal subunit protein eS10

1

6

High-throughput

0.445

High

935213

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

1004415

NOP14
Nucleolar protein 14

1

1

High-throughput

0.445

High

1112211

KRR1
KRR1 small subunit processome component homolog

1

8

High-throughput

0.445

High

1243592

RSBNL
Lysine-specific demethylase RSBN1L

1

2

High-throughput

0.445

High

1245514

CC137
Coiled-coil domain-containing protein 137

1

1

High-throughput

0.445

High

1247578

F111B
Serine protease FAM111B

1

2

High-throughput

0.445

High

1337427

SRFB1
Serum response factor-binding protein 1

1

2

High-throughput

0.445

High

1365469

ZN592
Zinc finger protein 592

1

5

High-throughput

0.445

High

1388440

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.445

High

1402790

STRBP
Spermatid perinuclear RNA-binding protein

1

13

High-throughput

0.445

High

1430783

GZF1
GDNF-inducible zinc finger protein 1

1

3

High-throughput

0.445

High

1437381

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.445

High

1450229

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

2

High-throughput

0.445

High

1453888

RBM27
RNA-binding protein 27

1

9

High-throughput

0.445

High

1453895

ZN346
Zinc finger protein 346

1

7

High-throughput

0.445

High

1453904

FCF1
rRNA-processing protein FCF1 homolog

1

2

High-throughput

0.445

High

157941

CTRO
Citron Rho-interacting kinase

1

14

High-throughput

0.437

High

272513

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

1088226

MERTK
Tyrosine-protein kinase Mer

1

6

High-throughput

0.437

High

1135142

CUL7
Cullin-7

1

3

High-throughput

0.437

High

1290784

ZCH18
Zinc finger CCCH domain-containing protein 18

1

14

High-throughput

0.437

High

1385896

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.437

High

1434100

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1453896

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

1148217

DLGP5
Disks large-associated protein 5

1

0

High-throughput

0.426

High

1435817

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.426

High

1453902

HPSE
Heparanase

1

0

High-throughput

0.426

High

58956

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.407

High

351026

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

5

High-throughput

0.407

High

1016271

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.407

High

1181348

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.407

High

1453891

NOL12
Nucleolar protein 12

1

1

High-throughput

0.407

High

1121608

URB2
Unhealthy ribosome biogenesis protein 2 homolog

2

0

High-throughput

0.328

High

1336642

PAPD5
Terminal nucleotidyltransferase 4B

1

0

High-throughput

0.279

Low

1409989

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.279

Low

1292453

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.249

Low

97196

CK098
Uncharacterized protein C11orf98

1

0

High-throughput

0.232

Low

1009350

PRR3
Proline-rich protein 3

1

0

High-throughput

0.232

Low

1178707

MTHSD
Methenyltetrahydrofolate synthase domain-containing protein

1

0

High-throughput

0.232

Low

1196182

RM51
Large ribosomal subunit protein mL51

1

0

High-throughput

0.232

Low

1349573

RM30
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.232

Low

1358279

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

0

High-throughput

0.232

Low

1453898

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025