HitPredict

Interactor 1: PIAS1 (O75925)
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)
Gene: PIAS1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

The method score is based on:

Property	Details
Experiments	31752909, 12393906
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008270 - zinc ion binding and 7 others more... GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity GO:0019899 - enzyme binding GO:0019904 - protein domain specific binding GO:0031625 - ubiquitin protein ligase binding GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043066 - negative regulation of apoptotic process
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	651
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024