HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.622

Property	Details
Experiments	11117529, 9920921
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0016607 - nuclear speck GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 621 Hs			1 920
+	Hs
		487883 PIAS3_HUMAN (1-621): 0: 666: 55.25		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		277899 PIAS1_HUMAN (1-621): 0: 653: 54.10		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487590 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		278206 PIAS2_HUMAN (1-621): 0: 811: 100.00		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		278207 PIAS2_HUMAN (1-621): 0: 811: 100.00		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		278312 PIAS2_HUMAN (1-621): 0: 811: 100.00		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		278210 PIAS2_HUMAN (1-621): 0: 811: 100.00		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		278228 PIAS2_HUMAN (1-621): 0: 811: 100.00		NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71
+	Hs
		370843 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		277875 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		1270069 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		277876 PIAS1_HUMAN (1-621): 0: 653: 54.10		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		278138 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		414536 PIAS3_HUMAN (1-621): 0: 666: 55.25		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		611538 PIAS3_HUMAN (1-621): 0: 666: 55.25		NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71
+	Hs
		277885 PIAS1_HUMAN (1-621): 0: 653: 54.10		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		277936 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71
+	Hs
		277974 PIAS1_HUMAN (1-621): 0: 653: 54.10		HNF4A_HUMAN (536-906): 1e-104: 335: 22.85
+	Hs
		278072 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H3_HUMAN (492-903): 9.35e-96: 310: 22.27
+	Hs
		510028 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		ERR1_HUMAN (556-856): 1.29e-95: 309: 30.49