HitPredict

Interactor 1: FLOT1 (O75955)
Flotillin-1
Gene: FLOT1

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35140242
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032728 - positive regulation of interferon-beta production GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0071360 - cellular response to exogenous dsRNA
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 427
+	Hs
		1052392 FLOT2_HUMAN (4-419): 1.33e-139: 407: 47.61		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		279521 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		IRF8_HUMAN (7-387): 6.94e-148: 428: 27.32
+	Hs
		1052399 FLOT2_HUMAN (4-419): 1.33e-139: 407: 47.61		IRF4_HUMAN (7-399): 9.49e-152: 439: 27.97
+	Hs
		971730 FLOT2_HUMAN (4-419): 1.33e-139: 407: 47.61		IRF8_HUMAN (7-387): 6.94e-148: 428: 27.32
+	Hs
		1039451 FLOT2_HUMAN (4-419): 1.33e-139: 407: 47.61		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		279416 FLOT1_HUMAN (1-427): 3.27e-145: 421: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23