HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	22266820, 25909880, 26285145, 35831895
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 485 Hs			1 685
+	Hs
		475927 RFWD3_HUMAN (140-483): 1.84e-37: 148: 16.99		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475328 RO52_HUMAN (389-483): 7.64e-26: 112: 31.25		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476247 UHRF1_HUMAN (206-472): 3.2e-24: 108: 11.96		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476418 TRI39_HUMAN (394-483): 7.45e-24: 106: 29.03		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476330 TRIM5_HUMAN (389-485): 8.62e-24: 105: 23.81		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475297 TRI27_HUMAN (392-478): 1.06e-22: 103: 21.11		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475680 TRI26_HUMAN (391-482): 8.35e-23: 103: 26.32		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476078 COP1_HUMAN (379-472): 2.35e-22: 102: 24.47		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476635 TRI17_HUMAN (390-485): 1.49e-22: 102: 21.10		UBC_HUMAN (1-685): 0: 846: 100.00
+	Xl
		78542 UHRF1_XENLA (206-472): 1.12e-31: 130: 14.13		Q7SY79_XENLA (77-685): 0: 744: 99.84
+	Xl
		1186351 NF7B_XENLA (263-483): 5.13e-28: 119: 18.42		Q7SY79_XENLA (77-685): 0: 744: 99.84
+	Xl
		1125746 CHFR_XENLA (280-481): 2.8e-21: 98.9: 18.87		Q7SY79_XENLA (77-685): 0: 744: 99.84
+	Sc
		477459 IRC20_YEAST (232-473): 1.32e-24: 110: 16.53		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	At
		1091974 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		476671 RO52_MOUSE (385-483): 2.42e-26: 113: 24.00		UBB_MOUSE (457-685): 2.3e-86: 275: 99.56
+	Mm
		924236 RO52_MOUSE (385-483): 2.42e-26: 113: 24.00		RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00
+	Mm
		476831 RO52_MOUSE (385-483): 2.42e-26: 113: 24.00		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Xl
		923941 CHFR_XENLA (280-481): 2.8e-21: 98.9: 18.87		UBIQP_XENLA (594-685): 1.96e-29: 116: 98.91
+	Hs
		475134 TRI11_HUMAN (392-472): 5.39e-24: 106: 26.19		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475177 TRIM5_HUMAN (389-485): 8.62e-24: 105: 23.81		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70