Protein: VPS4A
Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4)

Gene: VPS4A
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9UN37

Gene Ontology (top 5):
GO:0000916 - actomyosin contractile ring contraction
GO:0000922 - spindle pole
GO:0001778 - plasma membrane repair
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1446002

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

4

7

Small-scale

0.895

High

276932

VPS4B
Vacuolar protein sorting-associated protein 4B

3

17

High-throughput

0.861

High

1439649

CHM1A
Charged multivesicular body protein 1a

6

20

Small-scale

0.741

High

1395638

ANCHR
Abscission/NoCut checkpoint regulator

5

5

Small-scale

0.718

High

564558

CFTR
Cystic fibrosis transmembrane conductance regulator

4

7

High-throughput

0.691

High

221893

CHM2A
Charged multivesicular body protein 2a

3

20

Small-scale

0.664

High

1462134

VPS4A
Vacuolar protein sorting-associated protein 4A

1

16

High-throughput

0.656

High

1273186

CHM1B
Charged multivesicular body protein 1b

3

20

Small-scale

0.651

High

1417749

CHM4A
Charged multivesicular body protein 4a

3

20

Small-scale

0.645

High

925695

IST1
IST1 homolog

2

8

High-throughput

0.628

High

243286

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.618

High

626402

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

13

High-throughput

0.618

High

1067836

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.618

High

1433470

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.618

High

1450639

ARL8B
ADP-ribosylation factor-like protein 8B

2

12

High-throughput

0.611

High

1453651

CHMP5
Charged multivesicular body protein 5

2

20

Small-scale

0.611

High

348894

CLIC3
Chloride intracellular channel protein 3

2

4

High-throughput

0.606

High

1385915

CHM4C
Charged multivesicular body protein 4c

2

20

Small-scale

0.586

High

342369

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.586

High

169794

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

4

Small-scale

0.584

High

373490

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

1462137

CHMP3
Charged multivesicular body protein 3

2

20

Small-scale

0.584

High

944098

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.575

High

178442

NPC1
NPC intracellular cholesterol transporter 1

1

2

Small-scale

0.561

High

1209795

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.552

High

944907

PCBP4
Poly(rC)-binding protein 4

1

8

High-throughput

0.536

High

1116132

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.536

High

1287904

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

5

High-throughput

0.536

High

1326265

SESQ1
Sesquipedalian-1

1

13

High-throughput

0.536

High

1431009

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.536

High

1451531

BABA1
BRISC and BRCA1-A complex member 1

1

1

High-throughput

0.536

High

1461524

INTU
Protein inturned

1

1

High-throughput

0.536

High

1272010

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1371149

IRF7
Interferon regulatory factor 7

1

0

High-throughput

0.513

High

1409905

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1413873

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1433123

CHM4B
Charged multivesicular body protein 4b

1

19

High-throughput

0.508

High

186119

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.501

High

1462136

CHM2B
Charged multivesicular body protein 2b

1

20

Small-scale

0.501

High

791837

SYUA
Alpha-synuclein

1

3

High-throughput

0.481

High

157985

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

258353

TRI13
E3 ubiquitin-protein ligase TRIM13

1

11

High-throughput

0.479

High

377778

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.479

High

473179

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

565737

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

7

High-throughput

0.479

High

596420

H12
Histone H1.2

1

6

High-throughput

0.479

High

607222

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

630089

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

773305

MYH10
Myosin-10

1

2

High-throughput

0.479

High

831644

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

971286

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

992109

RL38
Large ribosomal subunit protein eL38

1

4

High-throughput

0.479

High

1052856

DUSP2
Dual specificity protein phosphatase 2

1

8

High-throughput

0.479

High

1107329

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1114650

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1147511

RHEB
GTP-binding protein Rheb

1

7

High-throughput

0.479

High

1163883

DUS6
Dual specificity protein phosphatase 6

1

8

High-throughput

0.479

High

1178460

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1233574

LTOR1
Ragulator complex protein LAMTOR1

1

1

Small-scale

0.479

High

1249325

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

1256085

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

1313878

S15A3
Solute carrier family 15 member 3

1

4

High-throughput

0.479

High

1316166

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

3

Small-scale

0.479

High

1330977

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1364684

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

1370672

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

6

High-throughput

0.479

High

1384305

SH3K1
SH3 domain-containing kinase-binding protein 1

1

5

Small-scale

0.479

High

1397554

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1429393

SPRTN
DNA-dependent metalloprotease SPRTN

1

4

High-throughput

0.479

High

1434226

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.479

High

1435452

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

1448324

FBX6
F-box only protein 6

1

5

High-throughput

0.479

High

1459307

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1460851

KCND3
A-type voltage-gated potassium channel KCND3

1

5

Small-scale

0.479

High

1462135

DUS12
Dual specificity protein phosphatase 12

1

8

High-throughput

0.479

High

1326950

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

530577

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

652267

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.445

High

1119364

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

1227704

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.445

High

1326146

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.445

High

1335777

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.445

High

1328772

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

4

Small-scale

0.437

High

255292

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

104247

F5H1C8
Solute carrier family 15 member 3

1

4

High-throughput

0.407

High

1325951

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1451191

TM248
Transmembrane protein 248

1

0

High-throughput

0.279

Low

1388078

MTBP
Mdm2-binding protein

1

0

High-throughput

0.249

Low

1363488

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025