HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	31792955, 22589545
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 485 Hs			1 145
+	Hs
		282581 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		282607 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		282595 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		282705 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E3_HUMAN (2-143): 6.26e-57: 178: 23.08
+	Hs
		282716 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E2_HUMAN (2-143): 7.87e-57: 177: 23.08
+	Hs
		282582 RNF8_HUMAN (1-485): 0: 523: 100.00		UB2E1_HUMAN (1-143): 2.16e-56: 176: 22.92
+	Mm
		1257412 RNF8_MOUSE (1-484): 3.26e-177: 508: 71.05		UB2V1_MOUSE (3-145): 3.03e-58: 179: 85.32
+	Mm
		1194999 CHFR_MOUSE (37-474): 4.95e-91: 292: 19.68		UB2V1_MOUSE (3-145): 3.03e-58: 179: 85.32
+	Hs
		1290127 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27
+	Hs
		849404 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		919820 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		1282325 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E3_HUMAN (2-143): 6.26e-57: 178: 23.08
+	Hs
		895874 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		1290120 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E2_HUMAN (2-143): 7.87e-57: 177: 23.08
+	Hs
		851866 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UB2E1_HUMAN (1-143): 2.16e-56: 176: 22.92
+	Hs
		930349 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	At
		639387 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBC1_ARATH (7-144): 6.09e-58: 178: 19.42
+	At
		790157 BRE1B_ARATH (137-446): 1.13e-41: 160: 17.74		UBC2_ARATH (7-144): 1.19e-57: 178: 18.71
+	Hs
		849415 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		895886 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06