Protein: IRF4
Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)

Gene: IRF4
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q15306

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838235

STAT6
Signal transducer and activator of transcription 6

3

20

Small-scale

0.875

High

1145803

IRF4
Interferon regulatory factor 4

3

15

Small-scale

0.827

High

1132021

STAT4
Signal transducer and activator of transcription 4

2

20

Small-scale

0.789

High

832723

BCL6
B-cell lymphoma 6 protein

4

5

Small-scale

0.702

High

1145805

BATF
Basic leucine zipper transcriptional factor ATF-like

1

2

High-throughput

0.698

High

626234

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

20

Small-scale

0.657

High

609931

SPI1
Transcription factor PU.1

3

10

Small-scale

0.650

High

1037796

IRF8
Interferon regulatory factor 8

1

15

Small-scale

0.618

High

1067354

EP300
Histone acetyltransferase p300

1

17

High-throughput

0.618

High

1045315

TF65
Transcription factor p65

2

20

Small-scale

0.601

High

1106335

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

20

Small-scale

0.601

High

1145835

MYD88
Myeloid differentiation primary response protein MyD88

2

20

Small-scale

0.601

High

1145850

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.601

High

905570

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.586

High

1145817

TLK2
Serine/threonine-protein kinase tousled-like 2

1

3

High-throughput

0.586

High

214432

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

2

1

Small-scale

0.584

High

378567

IL1B
Interleukin-1 beta

2

2

Small-scale

0.584

High

425515

ISG15
Ubiquitin-like protein ISG15

2

10

Small-scale

0.584

High

606798

CEBPB
CCAAT/enhancer-binding protein beta

2

3

Small-scale

0.584

High

749477

C2TA
MHC class II transactivator

2

7

Small-scale

0.584

High

1048859

REL
Proto-oncogene c-Rel

2

20

Small-scale

0.584

High

1145813

SEN54
tRNA-splicing endonuclease subunit Sen54

2

0

High-throughput

0.580

High

327596

ELP1
Elongator complex protein 1

1

0

High-throughput

0.561

High

1094553

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.561

High

211227

HXC11
Homeobox protein Hox-C11

1

7

High-throughput

0.541

High

1090652

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.541

High

1145830

HXB13
Homeobox protein Hox-B13

1

7

High-throughput

0.541

High

1145852

ETV7
Transcription factor ETV7

1

10

High-throughput

0.541

High

446110

FCER2
Low affinity immunoglobulin epsilon Fc receptor

2

1

Small-scale

0.533

High

1038624

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

Small-scale

0.529

High

1145829

PROX1
Prospero homeobox protein 1

1

0

High-throughput

0.518

High

963511

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.515

High

1145814

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.513

High

1145818

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

1145833

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

126312

TLR4
Toll-like receptor 4

1

14

Small-scale

0.479

High

137331

ELL2
RNA polymerase II elongation factor ELL2

1

1

Small-scale

0.479

High

154698

ARI1A
AT-rich interactive domain-containing protein 1A

1

9

High-throughput

0.479

High

161473

KMT2D
Histone-lysine N-methyltransferase 2D

1

7

High-throughput

0.479

High

174354

ZN609
Zinc finger protein 609

1

5

High-throughput

0.479

High

194568

KDM6A
Lysine-specific demethylase 6A

1

4

High-throughput

0.479

High

282721

E2F6
Transcription factor E2F6

1

1

High-throughput

0.479

High

289151

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

340890

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

20

Small-scale

0.479

High

372087

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.479

High

424324

IL4
Interleukin-4

1

3

Small-scale

0.479

High

464966

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

505564

ATX1L
Ataxin-1-like

1

1

High-throughput

0.479

High

651336

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.479

High

760757

CD68
Macrosialin

1

2

Small-scale

0.479

High

893656

MNX1
Motor neuron and pancreas homeobox protein 1

1

6

High-throughput

0.479

High

903162

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

4

High-throughput

0.479

High

916098

NKX25
Homeobox protein Nkx-2.5

1

4

High-throughput

0.479

High

925925

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.479

High

927306

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

1025352

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.479

High

1029997

RELB
Transcription factor RelB

1

20

Small-scale

0.479

High

1032757

SATB1
DNA-binding protein SATB1

1

2

High-throughput

0.479

High

1047824

TLE1
Transducin-like enhancer protein 1

1

3

High-throughput

0.479

High

1048522

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1061701

TLE5
TLE family member 5

1

2

High-throughput

0.479

High

1087751

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1124811

FLOT2
Flotillin-2

1

6

High-throughput

0.479

High

1145804

SSXT
Protein SSXT

1

5

High-throughput

0.479

High

1145806

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

1145809

ARID2
AT-rich interactive domain-containing protein 2

1

7

High-throughput

0.479

High

1145810

NIPBL
Nipped-B-like protein

1

3

High-throughput

0.479

High

1145811

BCOR
BCL-6 corepressor

1

6

High-throughput

0.479

High

1145812

PAXI1
PAX-interacting protein 1

1

2

High-throughput

0.479

High

1145816

PB1
Protein polybromo-1

1

4

High-throughput

0.479

High

1145819

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

2

Small-scale

0.479

High

1145820

FOXP4
Forkhead box protein P4

1

8

High-throughput

0.479

High

1145821

STAG2
Cohesin subunit SA-2

1

1

Small-scale

0.479

High

1145822

KMT2C
Histone-lysine N-methyltransferase 2C

1

7

High-throughput

0.479

High

1145823

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

4

High-throughput

0.479

High

1145824

ARI1B
AT-rich interactive domain-containing protein 1B

1

11

High-throughput

0.479

High

1145825

KDM2B
Lysine-specific demethylase 2B

1

1

High-throughput

0.479

High

1145827

DPF1
Zinc finger protein neuro-d4

1

8

High-throughput

0.479

High

1145828

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

1145832

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.479

High

1145834

CIC
Protein capicua homolog

1

6

High-throughput

0.479

High

1145837

PCGF1
Polycomb group RING finger protein 1

1

9

High-throughput

0.479

High

1145839

SSBP3
Single-stranded DNA-binding protein 3

1

1

High-throughput

0.479

High

1145843

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.479

High

1145845

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

2

High-throughput

0.479

High

1145846

TCF20
Transcription factor 20

1

6

High-throughput

0.479

High

1145847

ZN608
Zinc finger protein 608

1

3

High-throughput

0.479

High

1145848

PRR12
Proline-rich protein 12

1

7

High-throughput

0.479

High

1145849

SATB2
DNA-binding protein SATB2

1

2

High-throughput

0.479

High

1145853

NCOR2
Nuclear receptor corepressor 2

1

3

High-throughput

0.479

High

1145854

NCOA3
Nuclear receptor coactivator 3

1

3

High-throughput

0.479

High

1145807

PRC2B
Protein PRRC2B

1

8

High-throughput

0.470

High

144430

SCD
Stearoyl-CoA desaturase

1

0

Small-scale

0.458

High

290007

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

549441

CD20
B-lymphocyte antigen CD20

1

0

Small-scale

0.458

High

666831

CCNC
Cyclin-C

1

0

Small-scale

0.458

High

698680

CALX
Calnexin

1

0

Small-scale

0.458

High

1127831

ERG1
Squalene monooxygenase

1

0

Small-scale

0.458

High

1132658

MEF2D
Myocyte-specific enhancer factor 2D

1

0

High-throughput

0.458

High

1145815

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.458

High

1145836

PYGO2
Pygopus homolog 2

1

0

High-throughput

0.458

High

1145844

PIM2
Serine/threonine-protein kinase pim-2

1

0

Small-scale

0.458

High

1145851

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.458

High

1033843

SPIB
Transcription factor Spi-B

1

10

High-throughput

0.457

High

1145840

DEFI6
Differentially expressed in FDCP 6 homolog

1

3

Small-scale

0.457

High

1145831

CUL5
Cullin-5

1

2

High-throughput

0.445

High

712732

IL12A
Interleukin-12 subunit alpha

1

7

Small-scale

0.437

High

1145808

OTUD1
OTU domain-containing protein 1

1

4

Small-scale

0.437

High

542037

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.408

High

1145838

Q9BU62
BAT2L protein

1

1

High-throughput

0.407

High

1145826

GIPC2
PDZ domain-containing protein GIPC2

2

0

High-throughput

0.316

High

1145841

YTDC2
3'-5' RNA helicase YTHDC2

1

0

High-throughput

0.306

High

1145842

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025