HitPredict

Interactor 1: HCN1 (O88704)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2)
Gene: HCN1

Interactor 2: GIT1 (Q68FF6)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1)
Gene: GIT1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030425 - dendrite GO:0098978 - glutamatergic synapse
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 910 Mm			1 770
+	Hs
		240271 HCN1_HUMAN (1-910): 0: 666: 90.24		AGAP1_HUMAN (2-236): 4.18e-55: 205: 31.93
+	Hs
		240145 HCN1_HUMAN (1-910): 0: 666: 90.24		AGAP3_HUMAN (2-224): 1.24e-52: 198: 33.63
+	Hs
		240146 HCN1_HUMAN (1-910): 0: 666: 90.24		ARAP1_HUMAN (8-205): 2.17e-49: 190: 29.35
+	Hs
		60257 HCN1_HUMAN (1-910): 0: 666: 90.24		POTEF_HUMAN (52-620): 2.03e-40: 162: 12.59
+	Hs
		239734 HCN1_HUMAN (1-910): 0: 666: 90.24		POTEJ_HUMAN (52-620): 2.78e-40: 161: 13.10
+	Hs
		166861 HCN1_HUMAN (1-910): 0: 666: 90.24		ANR28_HUMAN (54-365): 8.87e-34: 141: 16.31
+	Hs
		239969 HCN1_HUMAN (1-910): 0: 666: 90.24		ANK3_HUMAN (174-528): 8.05e-33: 139: 10.36
+	Hs
		239946 HCN1_HUMAN (1-910): 0: 666: 90.24		ANK2_HUMAN (89-573): 7.15e-31: 133: 11.72
+	Hs
		240190 HCN1_HUMAN (1-910): 0: 666: 90.24		TANC2_HUMAN (179-479): 2.76e-15: 82.6: 11.18