Protein: GHC1
Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)

Gene: GHC1, SLC25A22
Organism: Homo sapiens
Interactions: 215
UniProt ID: Q9H936

Gene Ontology (top 5):
GO:0005280 - amino acid:proton symporter activity
GO:0005313 - L-glutamate transmembrane transporter activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006811 - monoatomic ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431153

GHC2
Mitochondrial glutamate carrier 2

6

15

High-throughput

0.940

High

242954

PRKN
E3 ubiquitin-protein ligase parkin

3

13

High-throughput

0.640

High

1211303

DNLZ
DNL-type zinc finger protein

3

0

High-throughput

0.638

High

774629

BASI
Basigin

2

8

High-throughput

0.611

High

1327598

WDTC1
WD and tetratricopeptide repeats protein 1

3

8

High-throughput

0.609

High

412626

NTRK1
High affinity nerve growth factor receptor

2

18

High-throughput

0.594

High

584584

VAV
Proto-oncogene vav

3

8

High-throughput

0.578

High

401498

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

12

High-throughput

0.571

High

486709

FGR
Tyrosine-protein kinase Fgr

2

6

High-throughput

0.571

High

578545

BRAF
Serine/threonine-protein kinase B-raf

2

12

High-throughput

0.571

High

565713

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

5

High-throughput

0.558

High

1101191

CLN3
Battenin

2

5

Small-scale

0.558

High

1209670

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

11

High-throughput

0.552

High

170538

RAB7L
Ras-related protein Rab-7L1

1

4

High-throughput

0.536

High

521440

ARAF
Serine/threonine-protein kinase A-Raf

1

12

High-throughput

0.536

High

845137

EAA3
Excitatory amino acid transporter 3

1

6

High-throughput

0.536

High

944959

RAB38
Ras-related protein Rab-38

1

3

High-throughput

0.536

High

1329193

S15A4
Solute carrier family 15 member 4

1

4

Small-scale

0.536

High

927140

ATX3
Ataxin-3

2

3

Small-scale

0.533

High

440213

LCK
Tyrosine-protein kinase Lck

2

6

High-throughput

0.521

High

622479

ELK1
ETS domain-containing protein Elk-1

2

4

High-throughput

0.521

High

1096504

PAK1
Serine/threonine-protein kinase PAK 1

2

6

High-throughput

0.521

High

1097117

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

2

9

High-throughput

0.521

High

1178688

RHG31
Rho GTPase-activating protein 31

2

4

High-throughput

0.521

High

1259507

TBA1A
Tubulin alpha-1A chain

2

14

High-throughput

0.521

High

1334932

SERB1
SERPINE1 mRNA-binding protein 1

2

6

High-throughput

0.521

High

885710

CASP4
Caspase-4

1

4

High-throughput

0.515

High

1152473

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.515

High

167976

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

6

High-throughput

0.489

High

318162

IPO13
Importin-13

1

1

High-throughput

0.489

High

427945

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.489

High

787078

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.489

High

876645

NEST
Nestin

1

4

High-throughput

0.489

High

922285

LIMK1
LIM domain kinase 1

1

15

High-throughput

0.489

High

922335

LIMK2
LIM domain kinase 2

1

3

High-throughput

0.489

High

1104493

ILK
Scaffold protein ILK

1

8

High-throughput

0.489

High

1114322

CUL3
Cullin-3

1

15

High-throughput

0.489

High

1115066

CUL4A
Cullin-4A

1

15

High-throughput

0.489

High

1116021

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.489

High

1177196

MICB
MHC class I polypeptide-related sequence B

1

5

High-throughput

0.489

High

1207302

KRBX4
KRAB domain-containing protein 4

1

2

High-throughput

0.489

High

1251958

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.489

High

1252839

NFXL1
NF-X1-type zinc finger protein NFXL1

1

8

High-throughput

0.489

High

1289369

ST32C
Serine/threonine-protein kinase 32C

1

11

High-throughput

0.489

High

1436755

AGO4
Protein argonaute-4

1

9

High-throughput

0.489

High

1436764

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

3

High-throughput

0.489

High

1436772

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.489

High

1035923

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1367300

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1420884

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

9

High-throughput

0.479

High

1428361

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

10

High-throughput

0.479

High

411056

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

9

High-throughput

0.457

High

439848

INSR
Insulin receptor

1

17

High-throughput

0.457

High

1157069

NTRK3
NT-3 growth factor receptor

1

18

High-throughput

0.457

High

141663

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

High-throughput

0.445

High

530385

TAU
Microtubule-associated protein tau

1

18

High-throughput

0.445

High

626364

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

High-throughput

0.445

High

653574

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

788209

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

1089873

ILF3
Interleukin enhancer-binding factor 3

1

3

High-throughput

0.445

High

1363328

DDX1
ATP-dependent RNA helicase DDX1

1

6

High-throughput

0.445

High

1436752

SYCM
Probable cysteine--tRNA ligase, mitochondrial

1

1

High-throughput

0.445

High

106665

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

194352

R113A
E3 ubiquitin-protein ligase RNF113A

1

4

High-throughput

0.437

High

284417

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

5

Small-scale

0.437

High

294339

CD123
Translation initiation factor eIF2 assembly protein

1

7

High-throughput

0.437

High

316024

RECQ4
ATP-dependent DNA helicase Q4

1

12

High-throughput

0.437

High

332115

MRP6
ATP-binding cassette sub-family C member 6

1

1

Small-scale

0.437

High

342327

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.437

High

373171

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.437

High

377725

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

3

High-throughput

0.437

High

390766

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

714435

PML
Protein PML

1

19

High-throughput

0.437

High

767338

MERL
Merlin

1

6

High-throughput

0.437

High

785460

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.437

High

831446

CCNF
Cyclin-F

1

7

High-throughput

0.437

High

837847

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.437

High

897396

CDK7
Cyclin-dependent kinase 7

1

9

High-throughput

0.437

High

897978

CDK9
Cyclin-dependent kinase 9

1

14

High-throughput

0.437

High

920281

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.437

High

971098

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.437

High

1097566

CBX3
Chromobox protein homolog 3

1

7

High-throughput

0.437

High

1100394

TIF1B
Transcription intermediary factor 1-beta

1

17

High-throughput

0.437

High

1107220

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.437

High

1129753

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.437

High

1138071

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.437

High

1140879

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1178382

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

1201898

PKHG4
Puratrophin-1

1

6

High-throughput

0.437

High

1218662

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.437

High

1229684

VIR
Protein virilizer homolog

1

5

High-throughput

0.437

High

1249219

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1252974

BAKOR
Beclin 1-associated autophagy-related key regulator

1

5

High-throughput

0.437

High

1255576

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1276803

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1286908

TM11B
Transmembrane protease serine 11B

1

12

High-throughput

0.437

High

1339715

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.437

High

1348212

TIP
T-cell immunomodulatory protein

1

4

High-throughput

0.437

High

1357424

DEP1B
DEP domain-containing protein 1B

1

5

High-throughput

0.437

High

1370950

TNR14
Tumor necrosis factor receptor superfamily member 14

1

7

High-throughput

0.437

High

1383246

CLUA1
Clusterin-associated protein 1

1

3

High-throughput

0.437

High

1391771

AURKB
Aurora kinase B

1

5

High-throughput

0.437

High

1397434

CI072
Guanine nucleotide exchange factor C9orf72

1

7

High-throughput

0.437

High

1403344

RUFY1
RUN and FYVE domain-containing protein 1

1

5

High-throughput

0.437

High

1404768

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.437

High

1410139

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.437

High

1428539

DDX24
ATP-dependent RNA helicase DDX24

1

7

High-throughput

0.437

High

1433439

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

15

High-throughput

0.437

High

1435297

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.437

High

1436756

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

High-throughput

0.437

High

1436757

ANLN
Anillin

1

6

High-throughput

0.437

High

1436758

FBX6
F-box only protein 6

1

10

High-throughput

0.437

High

1436759

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.437

High

1436760

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

5

High-throughput

0.437

High

1436761

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.437

High

1436763

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.437

High

1436769

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

1436771

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.437

High

914754

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.426

High

963024

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.426

High

1394482

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.426

High

156

A0A024R6X4
PLEKHG4

1

6

High-throughput

0.407

High

47886

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

131512

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.407

High

188036

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

6

High-throughput

0.407

High

245007

KATIP
Katanin-interacting protein

1

1

High-throughput

0.407

High

255214

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

260469

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.407

High

280826

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.407

High

330512

LC7L3
Luc7-like protein 3

1

1

High-throughput

0.407

High

419209

H2A1B
Histone H2A type 1-B/E

1

5

High-throughput

0.407

High

485734

RU2A
U2 small nuclear ribonucleoprotein A'

1

1

High-throughput

0.407

High

521948

H14
Histone H1.4

1

1

High-throughput

0.407

High

564382

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.407

High

596361

H12
Histone H1.2

1

1

High-throughput

0.407

High

608754

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

High-throughput

0.407

High

620592

NUCL
Nucleolin

1

4

High-throughput

0.407

High

655341

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

High-throughput

0.407

High

674333

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.407

High

685734

U2AF2
Splicing factor U2AF 65 kDa subunit

1

9

High-throughput

0.407

High

839373

MTOR
Serine/threonine-protein kinase mTOR

1

5

High-throughput

0.407

High

875784

PRC2A
Protein PRRC2A

1

6

High-throughput

0.407

High

889199

RBM25
RNA-binding protein 25

1

1

High-throughput

0.407

High

900165

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.407

High

900515

FXR2
RNA-binding protein FXR2

1

1

High-throughput

0.407

High

939438

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

3

High-throughput

0.407

High

944073

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

16

High-throughput

0.407

High

988213

TRA2B
Transformer-2 protein homolog beta

1

7

High-throughput

0.407

High

1016618

SRSF3
Serine/arginine-rich splicing factor 3

1

8

High-throughput

0.407

High

1027764

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.407

High

1029553

SRSF2
Serine/arginine-rich splicing factor 2

1

3

High-throughput

0.407

High

1058939

ZO1
Tight junction protein 1

1

7

High-throughput

0.407

High

1059965

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

High-throughput

0.407

High

1061155

SRSF1
Serine/arginine-rich splicing factor 1

1

6

High-throughput

0.407

High

1062116

SRSF4
Serine/arginine-rich splicing factor 4

1

4

High-throughput

0.407

High

1099541

SRSF6
Serine/arginine-rich splicing factor 6

1

5

High-throughput

0.407

High

1120341

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

3

High-throughput

0.407

High

1121746

SAFB2
Scaffold attachment factor B2

1

2

High-throughput

0.407

High

1121883

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.407

High

1122165

UBP2L
Ubiquitin-associated protein 2-like

1

1

High-throughput

0.407

High

1132982

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.407

High

1141313

BRD3
Bromodomain-containing protein 3

1

7

High-throughput

0.407

High

1144476

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.407

High

1148479

SAFB1
Scaffold attachment factor B1

1

2

High-throughput

0.407

High

1148563

SF3B4
Splicing factor 3B subunit 4

1

3

High-throughput

0.407

High

1150822

SF01
Splicing factor 1

1

1

High-throughput

0.407

High

1160086

SRSF7
Serine/arginine-rich splicing factor 7

1

4

High-throughput

0.407

High

1160300

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.407

High

1214670

RBM26
RNA-binding protein 26

1

1

High-throughput

0.407

High

1227479

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.407

High

1241799

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.407

High

1270788

DDX46
Probable ATP-dependent RNA helicase DDX46

1

4

High-throughput

0.407

High

1278808

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.407

High

1326091

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.407

High

1329112

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.407

High

1335724

MOT11
Monocarboxylate transporter 11

1

9

High-throughput

0.407

High

1360482

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.407

High

1365760

GCN1
Stalled ribosome sensor GCN1

1

5

High-throughput

0.407

High

1368891

RBP56
TATA-binding protein-associated factor 2N

1

3

High-throughput

0.407

High

1369390

DDX17
Probable ATP-dependent RNA helicase DDX17

1

4

High-throughput

0.407

High

1383083

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.407

High

1387018

Q96D37
VAV1 protein

1

8

High-throughput

0.407

High

1405496

SCAFB
Protein SCAF11

1

2

High-throughput

0.407

High

1436762

ZO2
Tight junction protein 2

1

7

High-throughput

0.407

High

1436765

KMT2B
Histone-lysine N-methyltransferase 2B

1

7

High-throughput

0.407

High

1436770

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.407

High

833779

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.279

Low

1356732

TM263
Transmembrane protein 263

1

0

High-throughput

0.279

Low

1431901

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.279

Low

1436766

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.269

Low

646945

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

1161401

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.249

Low

1436753

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.249

Low

81733

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

0

High-throughput

0.232

Low

129442

MEN1
Menin

1

0

High-throughput

0.232

Low

187799

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.232

Low

228371

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.232

Low

295239

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.232

Low

574475

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.232

Low

770296

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.232

Low

925977

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.232

Low

949442

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.232

Low

978733

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

1126541

CAPR1
Caprin-1

1

0

High-throughput

0.232

Low

1131832

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.232

Low

1136495

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.232

Low

1198086

FA98B
Protein FAM98B

1

0

High-throughput

0.232

Low

1290155

THOC4
THO complex subunit 4

1

0

High-throughput

0.232

Low

1311725

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

0

High-throughput

0.232

Low

1403286

RBM15
RNA-binding protein 15

1

0

High-throughput

0.232

Low

1417191

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.232

Low

1421138

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.232

Low

1436754

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.232

Low

1436767

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.232

Low

1436768

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025