Protein: GHC1
Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)

Gene: GHC1, SLC25A22
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q9H936

Gene Ontology (top 5):
GO:0005280 - amino acid:proton symporter activity
GO:0005313 - L-glutamate transmembrane transporter activity
GO:0005743 - mitochondrial inner membrane
GO:0006811 - monoatomic ion transport
GO:0015183 - L-aspartate transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1328772

GHC2
Mitochondrial glutamate carrier 2

4

8

High-throughput

0.895

High

1234380

WDTC1
WD and tetratricopeptide repeats protein 1

3

8

High-throughput

0.609

High

228725

PRKN
E3 ubiquitin-protein ligase parkin

3

11

High-throughput

0.585

High

548751

VAV
Proto-oncogene vav

3

8

High-throughput

0.578

High

454847

FGR
Tyrosine-protein kinase Fgr

2

6

High-throughput

0.571

High

530976

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

5

High-throughput

0.558

High

726415

BASI
Basigin

2

8

High-throughput

0.558

High

1030644

CLN3
Battenin

2

5

Small-scale

0.558

High

1130602

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

11

High-throughput

0.552

High

385536

NTRK1
High affinity nerve growth factor receptor

2

16

High-throughput

0.543

High

792853

EAA3
Excitatory amino acid transporter 3

1

3

High-throughput

0.536

High

868335

ATX3
Ataxin-3

2

3

Small-scale

0.533

High

374889

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

12

High-throughput

0.521

High

411859

LCK
Tyrosine-protein kinase Lck

2

6

High-throughput

0.521

High

542917

BRAF
Serine/threonine-protein kinase B-raf

2

12

High-throughput

0.521

High

584276

ELK1
ETS domain-containing protein Elk-1

2

3

High-throughput

0.521

High

1026231

PAK1
Serine/threonine-protein kinase PAK 1

2

6

High-throughput

0.521

High

1026833

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

2

8

High-throughput

0.521

High

1101586

RHG31
Rho GTPase-activating protein 31

2

4

High-throughput

0.521

High

1175185

TBA1A
Tubulin alpha-1A chain

2

11

High-throughput

0.521

High

158547

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

6

High-throughput

0.489

High

160953

RAB7L
Ras-related protein Rab-7L1

1

4

High-throughput

0.489

High

297197

IPO13
Importin-13

1

1

High-throughput

0.489

High

400119

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.489

High

488807

ARAF
Serine/threonine-protein kinase A-Raf

1

12

High-throughput

0.489

High

738269

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.489

High

821819

NEST
Nestin

1

3

High-throughput

0.489

High

863803

LIMK1
LIM domain kinase 1

1

15

High-throughput

0.489

High

863848

LIMK2
LIM domain kinase 2

1

3

High-throughput

0.489

High

884455

RAB38
Ras-related protein Rab-38

1

2

High-throughput

0.489

High

1033559

ILK
Integrin-linked protein kinase

1

8

High-throughput

0.489

High

1042558

CUL3
Cullin-3

1

13

High-throughput

0.489

High

1043227

CUL4A
Cullin-4A

1

13

High-throughput

0.489

High

1100217

MICB
MHC class I polypeptide-related sequence B

1

4

High-throughput

0.489

High

1128404

KRBX4
KRAB domain-containing protein 4

1

1

High-throughput

0.489

High

1168418

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.489

High

1169237

NFXL1
NF-X1-type zinc finger protein NFXL1

1

7

High-throughput

0.489

High

1200407

ST32C
Serine/threonine-protein kinase 32C

1

11

High-throughput

0.489

High

1333985

AGO4
Protein argonaute-4

1

9

High-throughput

0.489

High

1333993

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

3

High-throughput

0.489

High

1333997

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.489

High

830295

CASP4
Caspase-4

1

4

High-throughput

0.470

High

383979

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

9

High-throughput

0.457

High

411496

INSR
Insulin receptor

1

17

High-throughput

0.457

High

1081606

NTRK3
NT-3 growth factor receptor

1

16

High-throughput

0.457

High

1235873

S15A4
Solute carrier family 15 member 4

1

4

Small-scale

0.445

High

182912

R113A
E3 ubiquitin-protein ligase RNF113A

1

4

High-throughput

0.437

High

267257

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

5

Small-scale

0.437

High

295267

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.437

High

319338

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.437

High

347916

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.437

High

352255

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

3

High-throughput

0.437

High

364439

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

668990

PML
Protein PML

1

17

High-throughput

0.437

High

719619

MERL
Merlin

1

6

High-throughput

0.437

High

736743

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.437

High

780121

CCNF
Cyclin-F

1

7

High-throughput

0.437

High

786136

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.437

High

841325

CDK7
Cyclin-dependent kinase 7

1

9

High-throughput

0.437

High

841886

CDK9
Cyclin-dependent kinase 9

1

14

High-throughput

0.437

High

909138

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.437

High

969998

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

1027266

CBX3
Chromobox protein homolog 3

1

7

High-throughput

0.437

High

1029885

TIF1B
Transcription intermediary factor 1-beta

1

16

High-throughput

0.437

High

1036090

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.437

High

1056992

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.437

High

1064163

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.437

High

1066716

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1101295

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

1123329

PKHG4
Puratrophin-1

1

6

High-throughput

0.437

High

1148788

VIR
Protein virilizer homolog

1

5

High-throughput

0.437

High

1165959

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1171749

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.437

High

1188878

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1198174

TM11B
Transmembrane protease serine 11B

1

11

High-throughput

0.437

High

1245188

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.437

High

1252207

TIP
T-cell immunomodulatory protein

1

4

High-throughput

0.437

High

1260778

DEP1B
DEP domain-containing protein 1B

1

5

High-throughput

0.437

High

1269641

ESR2
Estrogen receptor beta

1

17

High-throughput

0.437

High

1273170

TNR14
Tumor necrosis factor receptor superfamily member 14

1

7

High-throughput

0.437

High

1284239

CLUA1
Clusterin-associated protein 1

1

3

High-throughput

0.437

High

1292226

AURKB
Aurora kinase B

1

5

High-throughput

0.437

High

1302760

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.437

High

1304111

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.437

High

1309058

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.437

High

1319009

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

9

High-throughput

0.437

High

1326153

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

10

High-throughput

0.437

High

1326326

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

1330849

Q9H4D1
Protein kinase

1

15

High-throughput

0.437

High

1332616

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.437

High

1333986

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

High-throughput

0.437

High

1333987

ANLN
Anillin

1

6

High-throughput

0.437

High

1333988

FBX6
F-box only protein 6

1

9

High-throughput

0.437

High

1333989

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.437

High

1333990

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

5

High-throughput

0.437

High

1333991

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.437

High

1333992

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.437

High

1333995

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

1333996

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.437

High

156

A0A024R6X4
PLEKHG4

1

6

High-throughput

0.407

High

47692

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

230658

KATIP
Katanin-interacting protein

1

1

High-throughput

0.407

High

240186

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.407

High

497605

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.407

High

529733

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.407

High

587711

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

High-throughput

0.407

High

883644

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

16

High-throughput

0.407

High

1044160

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.407

High

1233206

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.407

High

1241622

MOT11
Monocarboxylate transporter 11

1

9

High-throughput

0.407

High

1287794

Q96D37
VAV1 protein

1

8

High-throughput

0.407

High

1132125

DNLZ
DNL-type zinc finger protein

3

0

High-throughput

0.347

High

782385

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.279

Low

1260154

TM263
Transmembrane protein 263

1

0

High-throughput

0.279

Low

1077341

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.269

Low

1333994

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.269

Low

309812

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.249

Low

1085682

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.249

Low

1333984

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.249

Low

1329428

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024