HitPredict

Interactor 1: STK10 (O94804)
Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)
Gene: STK10

Interactor 2: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 968 Hs			1 193
+	Hs
		296403 STK10_HUMAN (1-968): 0: 657: 100.00		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		296408 STK10_HUMAN (1-968): 0: 657: 100.00		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		296406 STK10_HUMAN (1-968): 0: 657: 100.00		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		647858 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		647868 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		436165 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00
+	Hs
		647872 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		647856 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		545213 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		900617 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		647867 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		925384 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		436371 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00
+	Hs
		647855 MARK3_HUMAN (10-757): 1.97e-167: 509: 16.34		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		951102 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		894157 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		545461 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		915778 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		892447 MARK2_HUMAN (19-757): 4.5e-163: 499: 16.08		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		545725 MRCKB_HUMAN (2-967): 2.23e-149: 485: 15.63		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12