HitPredict

Interactor 1: ACL6B (O94805)
Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B)
Gene: ACTL6B

Interactor 2: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~TIP49
Common GO terms	GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II GO:0016363 - nuclear matrix GO:0035267 - NuA4 histone acetyltransferase complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 463
+	Hs
		331618 ACL6A_HUMAN (1-426): 0: 777: 83.92		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		331619 ACL6A_HUMAN (1-426): 0: 777: 83.92		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Mm
		888134 ACL6A_MOUSE (1-426): 0: 774: 83.92		RUVB1_MOUSE (8-451): 0: 656: 42.67
+	Hs
		892121 ACTB_HUMAN (9-425): 0: 549: 35.49		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		930057 ACTG_HUMAN (9-425): 0: 549: 35.49		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		932462 ACTC_HUMAN (5-425): 0: 543: 36.11		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		296497 ACL6B_HUMAN (1-426): 0: 584: 100.00		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		892123 ACTB_HUMAN (9-425): 0: 549: 35.49		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		930058 ACTG_HUMAN (9-425): 0: 549: 35.49		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		932463 ACTC_HUMAN (5-425): 0: 543: 36.11		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Dm
		501453 ACT5_DROME (9-425): 0: 546: 36.45		RUVB1_DROME (8-452): 0: 619: 44.32
+	Dm
		1178496 Q7K012_DROME (1-426): 9.57e-180: 509: 55.96		RUVB1_DROME (8-452): 0: 619: 44.32
+	At
		1195611 ARP4_ARATH (5-426): 1.47e-123: 367: 40.90		Q9FJW0_ARATH (6-454): 0: 664: 76.22
+	At
		1195616 ARP4_ARATH (5-426): 1.47e-123: 367: 40.90		Q9M2X5_ARATH (6-453): 0: 663: 70.89
+	At
		1195613 ARP4_ARATH (5-426): 1.47e-123: 367: 40.90		RIN1_ARATH (9-451): 0: 645: 42.86
+	Sc
		887725 ACT_YEAST (10-425): 4.96e-82: 258: 37.08		RUVB2_YEAST (7-451): 0: 650: 68.76
+	Sc
		887667 ACT_YEAST (10-425): 4.96e-82: 258: 37.08		RUVB1_YEAST (12-451): 0: 605: 41.72