HitPredict

Interactor 1: TOX4 (O94842)
TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1)
Gene: TOX4

Interactor 2: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31248990
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 1365
+	Hs
		331701 HMGB1_HUMAN (139-302): 5.39e-28: 113: 20.23		NSD2_HUMAN (1-1365): 0: 980: 100.00
+	Mm
		1149777 TOX4_MOUSE (1-621): 2.12e-107: 338: 95.01		Q6AXH7_MOUSE (904-1188): 1.25e-58: 218: 22.48
+	Hs
		1080447 HMGX4_HUMAN (55-335): 2.61e-40: 157: 20.41		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Mm
		818678 SOX2_MOUSE (186-480): 7.81e-30: 121: 13.02		MSH6_MOUSE (179-558): 1.99e-63: 239: 21.52
+	Hs
		1080371 HM20A_HUMAN (133-423): 7.93e-36: 139: 16.56		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		996689 SSRP1_HUMAN (148-386): 3.7e-29: 124: 18.11		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		643350 HMGB2_HUMAN (139-314): 2.31e-31: 123: 18.38		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		818475 SOX2_HUMAN (185-480): 3.81e-31: 125: 13.61		EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43
+	Hs
		818358 SOX2_HUMAN (185-480): 3.81e-31: 125: 13.61		EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65
+	Hs
		818438 SOX2_HUMAN (185-480): 3.81e-31: 125: 13.61		SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74
+	Hs
		996877 SSRP1_HUMAN (148-386): 3.7e-29: 124: 18.11		SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74
+	Hs
		817951 SOX2_HUMAN (185-480): 3.81e-31: 125: 13.61		KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05
+	Hs
		975232 SSRP1_HUMAN (148-386): 3.7e-29: 124: 18.11		KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05
+	Hs
		818361 SOX2_HUMAN (185-480): 3.81e-31: 125: 13.61		NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33
+	Hs
		152611 SOX9_HUMAN (137-340): 2.15e-30: 127: 16.82		KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54
+	Hs
		152610 SOX2_HUMAN (185-480): 3.81e-31: 125: 13.61		KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54