HitPredict

Interactor 1: SRBS2 (O94875)
Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)
Gene: SORBS2

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	36931259, 24255178
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005925 - focal adhesion GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1100 Hs			1 246
+	Hs
		298967 SRBS2_HUMAN (1-1100): 0: 744: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		299007 SRBS2_HUMAN (1-1100): 0: 744: 100.00		V9HW98_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		298968 SRBS2_HUMAN (1-1100): 0: 744: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Mm
		910242 SRBS2_MOUSE (1-1100): 0: 711: 86.74		1433E_MOUSE (3-243): 4.39e-144: 405: 65.43
+	Hs
		298950 SRBS2_HUMAN (1-1100): 0: 744: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		298965 SRBS2_HUMAN (1-1100): 0: 744: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		298972 SRBS2_HUMAN (1-1100): 0: 744: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		298953 SRBS2_HUMAN (1-1100): 0: 744: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		360618 SPTA1_HUMAN (86-952): 5.28e-83: 299: 12.33		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Mm
		434798 SPTA1_MOUSE (86-952): 3.5e-66: 247: 11.24		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Hs
		909544 SPTN1_HUMAN (86-954): 3.53e-63: 238: 11.98		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683333 SPTN1_HUMAN (86-954): 3.53e-63: 238: 11.98		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Mm
		82753 B9EKJ1_MOUSE (86-954): 2.08e-63: 239: 12.30		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Hs
		927025 SPTN1_HUMAN (86-954): 3.53e-63: 238: 11.98		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Mm
		82777 B9EKJ1_MOUSE (86-954): 2.08e-63: 239: 12.30		1433B_MOUSE (1-246): 5.56e-141: 396: 98.78
+	Hs
		904543 SPTN1_HUMAN (86-954): 3.53e-63: 238: 11.98		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		981996 SPTN1_HUMAN (86-954): 3.53e-63: 238: 11.98		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		684024 SPTN1_HUMAN (86-954): 3.53e-63: 238: 11.98		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		683253 GRB2_HUMAN (743-923): 8.99e-28: 114: 17.90		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		646781 GRB2_HUMAN (743-923): 8.99e-28: 114: 17.90		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82