HitPredict

Interactor 1: FLOT1 (O75955)
Flotillin-1
Gene: FLOT1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	11001060, 36470425
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016600 - flotillin complex GO:0045121 - membrane raft
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 906
+	Hs
		651326 FLOT2_HUMAN (4-419): 1.34e-139: 407: 47.61		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		651158 STOM_HUMAN (8-217): 8.07e-21: 93.8: 16.67		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		651456 STML2_HUMAN (8-217): 5.7e-13: 71.8: 18.48		CBL_HUMAN (1-906): 0: 882: 100.00
+	Hs
		298996 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		K0754_HUMAN (395-735): 9.45e-34: 143: 11.14
+	Hs
		299455 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		PCLO_HUMAN (438-844): 8.51e-13: 75: 9.05
+	Hs
		299333 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		ASPP1_HUMAN (460-843): 3.23e-10: 66.1: 12.69