HitPredict

Interactor 1: FLOT1 (O75955)
Flotillin-1
Gene: FLOT1

Interactor 2: SRBS1 (Q9BX66)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: SORBS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.710

Property	Details
Experiments	15128873, 11001060, 11481476, 17548467, 15939299
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005925 - focal adhesion GO:0016600 - flotillin complex GO:0045121 - membrane raft
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 1292
+	Hs
		299184 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		SPTN1_HUMAN (305-902): 3.99e-65: 246: 13.41
+	Hs
		299214 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		ITSN1_HUMAN (492-1290): 3.41e-18: 93.3: 9.59
+	Mm
		148502 FLOT1_MOUSE (1-427): 4.93e-143: 416: 98.13		SRBS2_MOUSE (121-924): 1.18e-13: 78.3: 14.14
+	Hs
		298998 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		SRBS2_HUMAN (63-924): 1.62e-11: 71.4: 12.11
+	Hs
		298997 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		FCSD2_HUMAN (1186-1290): 6.22e-10: 65.8: 22.94
+	Hs
		250190 FLOT1_HUMAN (1-427): 3.28e-145: 421: 100.00		VINEX_HUMAN (852-938): 9.34e-09: 61.9: 27.59