Protein: SRBS2
Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)

Gene: SRBS2, SORBS2
Organism: Homo sapiens
Interactions: 88
UniProt ID: O94875

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211967

EFS
Embryonal Fyn-associated substrate

3

20

High-throughput

0.871

High

320202

SRBS2
Sorbin and SH3 domain-containing protein 2

3

17

High-throughput

0.861

High

320204

ABL1
Tyrosine-protein kinase ABL1

3

20

Small-scale

0.847

High

320205

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.785

High

155149

SOCS7
Suppressor of cytokine signaling 7

2

20

High-throughput

0.783

High

320250

ABI1
Abl interactor 1

2

20

High-throughput

0.783

High

221992

NCK2
Cytoplasmic protein NCK2

1

18

High-throughput

0.740

High

320241

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.724

High

320220

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.709

High

320263

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.698

High

320229

1433E
14-3-3 protein epsilon

3

9

High-throughput

0.676

High

320213

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.667

High

320230

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.665

High

320266

SH24A
SH2 domain-containing protein 4A

1

20

High-throughput

0.662

High

320271

DLGP4
Disks large-associated protein 4

3

20

Small-scale

0.658

High

320210

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.631

High

320212

AKT2
RAC-beta serine/threonine-protein kinase

1

10

High-throughput

0.621

High

320249

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

19

High-throughput

0.621

High

320255

WASF1
Actin-binding protein WASF1

2

20

Small-scale

0.620

High

320267

ANLN
Anillin

1

12

High-throughput

0.618

High

63163

VP37C
Vacuolar protein sorting-associated protein 37C

3

20

High-throughput

0.616

High

215886

SYNJ1
Synaptojanin-1

2

20

Small-scale

0.614

High

320211

1433T
14-3-3 protein theta

2

20

High-throughput

0.612

High

320227

1433G
14-3-3 protein gamma

2

20

High-throughput

0.612

High

133615

WASL
Actin nucleation-promoting factor WASL

2

20

High-throughput

0.606

High

187841

EIF3H
Eukaryotic translation initiation factor 3 subunit H

2

15

High-throughput

0.606

High

320238

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

High-throughput

0.606

High

320214

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

224564

ACTN4
Alpha-actinin-4

1

20

High-throughput

0.582

High

320233

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

20

High-throughput

0.575

High

320206

ACTN1
Alpha-actinin-1

1

20

Small-scale

0.573

High

320254

PALLD
Palladin

1

17

Small-scale

0.573

High

320221

WASP
Actin nucleation-promoting factor WAS

1

20

High-throughput

0.573

High

320235

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

Small-scale

0.561

High

320240

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.561

High

320234

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

320236

GOGA2
Golgin subfamily A member 2

2

20

High-throughput

0.553

High

320260

AP4AT
AP-4 complex accessory subunit Tepsin

2

1

High-throughput

0.553

High

156793

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.553

High

123535

MYO1C
Unconventional myosin-Ic

1

16

High-throughput

0.536

High

320208

FLNA
Filamin-A

1

20

High-throughput

0.536

High

320218

MYH9
Myosin-9

1

9

High-throughput

0.536

High

320222

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

16

High-throughput

0.536

High

320223

CAZA2
F-actin-capping protein subunit alpha-2

1

10

High-throughput

0.536

High

320228

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

14

High-throughput

0.536

High

320231

CLH1
Clathrin heavy chain 1

1

7

High-throughput

0.536

High

320247

DREB
Drebrin

1

20

High-throughput

0.536

High

320251

SYNPO
Synaptopodin

1

20

High-throughput

0.536

High

320256

MY18A
Unconventional myosin-XVIIIa

1

16

High-throughput

0.536

High

320237

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.515

High

320243

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.515

High

320225

NR1H2
Oxysterols receptor LXR-beta

1

13

High-throughput

0.508

High

320264

SEM6A
Semaphorin-6A

1

8

Small-scale

0.508

High

154378

DLGP1
Disks large-associated protein 1

1

20

Small-scale

0.501

High

320207

VINC
Vinculin

1

12

Small-scale

0.501

High

320226

AFAD
Afadin

1

20

Small-scale

0.501

High

320239

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

20

Small-scale

0.501

High

320215

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.481

High

320242

FAT1
Protocadherin Fat 1

1

6

Small-scale

0.481

High

179102

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

11

Small-scale

0.479

High

298998

FLOT1
Flotillin-1

1

7

Small-scale

0.479

High

320203

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.479

High

320216

CTNA1
Catenin alpha-1

1

10

High-throughput

0.479

High

320217

CTNB1
Catenin beta-1

1

6

High-throughput

0.479

High

320219

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

14

High-throughput

0.479

High

320224

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

320244

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

320246

MARE1
Microtubule-associated protein RP/EB family member 1

1

7

High-throughput

0.479

High

320257

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

320262

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

320265

CHM4B
Charged multivesicular body protein 4b

1

11

High-throughput

0.479

High

320269

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

320270

LIMA1
LIM domain and actin-binding protein 1

1

20

High-throughput

0.479

High

166595

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

High-throughput

0.470

High

320272

V9HW98
14-3-3 protein epsilon

1

9

High-throughput

0.470

High

320232

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.460

High

254688

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

320253

CCD89
Coiled-coil domain-containing protein 89

1

9

High-throughput

0.445

High

320261

ZBT18
Zinc finger and BTB domain-containing protein 18

1

10

High-throughput

0.445

High

104995

APRIO
Alternative prion protein

1

10

High-throughput

0.437

High

320209

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

3

High-throughput

0.437

High

320245

EEA1
Early endosome antigen 1

1

20

High-throughput

0.437

High

320248

SYNE3
Nesprin-3

1

20

High-throughput

0.437

High

320258

SNX27
Sorting nexin-27

1

20

High-throughput

0.437

High

320268

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.426

High

320259

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.407

High

320252

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.341

High


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Last updated: 11Aug2025