HitPredict

Interactor 1: PRP6 (O94906)
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene: PRPF6

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 941 Hs			1 551
+	Hs
		300086 PRP6_HUMAN (1-941): 0: 610: 100.00		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		300199 PRP6_HUMAN (1-941): 0: 610: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		1084606 CRNL1_HUMAN (521-932): 8.54e-41: 164: 12.50		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084498 CTR9_HUMAN (126-536): 3.3e-16: 85.7: 10.12		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084631 SYF1_HUMAN (109-527): 1.77e-12: 73.4: 13.78		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		174931 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Sc
		376625 PRP6_YEAST (4-924): 7.58e-80: 280: 21.50		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		175037 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		174849 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Mm
		665754 CTR9_MOUSE (126-536): 5.01e-16: 85.3: 10.12		PABP1_MOUSE (81-518): 3.65e-24: 108: 16.63
+	Hs
		174583 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Sc
		376611 CYC8_YEAST (641-915): 1.29e-13: 77.2: 17.12		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Sc
		376930 RRP5_YEAST (276-524): 4.45e-12: 72.5: 17.28		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		175154 OGT1_HUMAN (120-352): 4.99e-10: 65.7: 11.39		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59