HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Adaptin_N, Alpha_adaptinC2~Alpha_adaptin_C, Alpha_adaptinC2~Alpha_adaptinC2, Alpha_adaptinC2~B2-adapt-app_C
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0019901 - protein kinase binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 939 Hs			1 949
+	Hs
		302132 AP2A2_HUMAN (1-939): 0: 884: 100.00		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		321535 AP2A1_HUMAN (1-939): 0: 832: 78.47		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		321523 AP2A1_HUMAN (1-939): 0: 832: 78.47		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Mm
		567513 AP2A1_MOUSE (1-939): 0: 830: 79.33		AP2B1_MOUSE (1-949): 0: 944: 81.35
+	Dm
		954826 AP2A_DROME (3-939): 0: 819: 69.50		Q24253_DROME (1-949): 0: 851: 72.74
+	Hs
		212624 AP1G1_HUMAN (1-811): 0: 616: 25.12		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		925858 AP2B1_HUMAN (36-933): 0: 607: 16.62		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		302075 AP2A2_HUMAN (1-939): 0: 884: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Hs
		212616 AP1G1_HUMAN (1-811): 0: 616: 25.12		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	At
		286690 AP2A1_ARATH (8-939): 0: 711: 37.23		APBLC_ARATH (3-948): 0: 788: 57.01
+	At
		1228260 AP2A1_ARATH (8-939): 0: 711: 37.23		APBLB_ARATH (3-948): 0: 774: 56.69
+	At
		1228256 AP2A1_ARATH (8-939): 0: 711: 37.23		AP2A1_ARATH (13-946): 0: 627: 16.87
+	Sc
		647443 AP2A_YEAST (10-937): 0: 606: 25.44		AP2B_YEAST (1-579): 3.65e-82: 282: 31.95