HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	29643511, 28689657, 29378950, 11714696
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2799 Hs			1 154
+	Hs
		304110 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		304101 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		304280 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90
+	Hs
		304298 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		304080 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90
+	Hs
		304067 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2A_HUMAN (3-150): 7.79e-65: 196: 26.17
+	Hs
		304114 UBR5_HUMAN (1-2799): 0: 3949: 100.00		UBE2B_HUMAN (3-148): 8.21e-64: 193: 26.53
+	Hs
		849351 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919762 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895825 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		932538 HECW1_HUMAN (2170-2798): 2.44e-168: 568: 20.31		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		919889 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895935 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		849452 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919869 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895919 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		932588 HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		849451 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		895918 SMUF2_HUMAN (2405-2796): 3.89e-134: 442: 22.36		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		932580 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00