Protein: K22E
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)

Gene: K22E, KRT2
Organism: Homo sapiens
Interactions: 219
UniProt ID: P35908

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0003334 - keratinocyte development
GO:0005200 - structural constituent of cytoskeleton
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

280955

KRT38
Keratin, type I cuticular Ha8

5

20

High-throughput

0.939

High

444326

K1C19
Keratin, type I cytoskeletal 19

5

20

High-throughput

0.936

High

729096

K1H1
Keratin, type I cuticular Ha1

4

20

High-throughput

0.917

High

729113

K1C40
Keratin, type I cytoskeletal 40

4

20

High-throughput

0.917

High

531451

K1C13
Keratin, type I cytoskeletal 13

4

20

High-throughput

0.896

High

579997

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.875

High

280777

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

445010

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

729085

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

729128

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

729129

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

729145

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

729099

AINX
Alpha-internexin

1

20

High-throughput

0.691

High

49556

A1A4E9
Keratin 13

1

20

High-throughput

0.665

High

729063

GRB2
Growth factor receptor-bound protein 2

3

14

High-throughput

0.633

High

729171

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

3

20

High-throughput

0.633

High

280536

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.621

High

280859

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.621

High

408752

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.621

High

729086

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

729101

K1C24
Keratin, type I cytoskeletal 24

1

20

High-throughput

0.621

High

729114

K1C39
Keratin, type I cytoskeletal 39

1

20

High-throughput

0.621

High

729127

K1C28
Keratin, type I cytoskeletal 28

1

20

High-throughput

0.621

High

729070

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

301654

TRI37
E3 ubiquitin-protein ligase TRIM37

2

20

High-throughput

0.611

High

729076

MTM1
Myotubularin

2

1

High-throughput

0.611

High

346098

MYC
Myc proto-oncogene protein

2

12

High-throughput

0.584

High

729103

LARP7
La-related protein 7

2

11

High-throughput

0.584

High

581492

VCAM1
Vascular cell adhesion protein 1

2

5

High-throughput

0.571

High

70653

MYO9A
Unconventional myosin-IXa

1

4

High-throughput

0.536

High

150356

ZN195
Zinc finger protein 195

1

1

High-throughput

0.536

High

200513

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

High-throughput

0.536

High

317417

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.536

High

319741

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.536

High

362886

FINC
Fibronectin

1

6

High-throughput

0.536

High

729071

IFFO1
Non-homologous end joining factor IFFO1

1

19

High-throughput

0.536

High

729077

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

729078

CUL1
Cullin-1

1

20

High-throughput

0.536

High

729079

CUL2
Cullin-2

1

20

High-throughput

0.536

High

729080

CUL3
Cullin-3

1

20

High-throughput

0.536

High

729081

CUL4A
Cullin-4A

1

20

High-throughput

0.536

High

729082

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

729091

FL2D
Pre-mRNA-splicing regulator WTAP

1

6

High-throughput

0.536

High

729094

PCM1
Pericentriolar material 1 protein

1

5

High-throughput

0.536

High

729097

NEDD8
NEDD8

1

4

High-throughput

0.536

High

729109

CE350
Centrosome-associated protein 350

1

6

High-throughput

0.536

High

729111

HAUS3
HAUS augmin-like complex subunit 3

1

1

High-throughput

0.536

High

729120

FA83H
Protein FAM83H

1

5

High-throughput

0.536

High

729126

CSN6
COP9 signalosome complex subunit 6

1

11

High-throughput

0.536

High

729131

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

14

High-throughput

0.536

High

729133

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

1

High-throughput

0.536

High

729134

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

High-throughput

0.536

High

729136

CEP97
Centrosomal protein of 97 kDa

1

2

High-throughput

0.536

High

729141

RIN3
Ras and Rab interactor 3

1

4

High-throughput

0.536

High

729148

CSN5
COP9 signalosome complex subunit 5

1

16

High-throughput

0.536

High

729149

CUL5
Cullin-5

1

20

High-throughput

0.536

High

729155

DCNL1
DCN1-like protein 1

1

4

High-throughput

0.536

High

729159

NEUL4
Neuralized-like protein 4

1

2

High-throughput

0.536

High

729161

MPP9
M-phase phosphoprotein 9

1

1

High-throughput

0.536

High

729166

NUF2
Kinetochore protein Nuf2

1

9

High-throughput

0.536

High

729178

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

14

High-throughput

0.536

High

729181

MYO5C
Unconventional myosin-Vc

1

1

High-throughput

0.536

High

729185

MKS1
Tectonic-like complex member MKS1

1

8

High-throughput

0.536

High

729188

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

3

High-throughput

0.536

High

729191

IF172
Intraflagellar transport protein 172 homolog

1

5

High-throughput

0.536

High

729197

CP131
Centrosomal protein of 131 kDa

1

5

High-throughput

0.536

High

729198

CE164
Centrosomal protein of 164 kDa

1

5

High-throughput

0.536

High

729108

RC3H1
Roquin-1

2

7

High-throughput

0.533

High

648669

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

318932

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

729046

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

729053

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.513

High

729110

ZN318
Zinc finger protein 318

1

0

High-throughput

0.513

High

729130

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.513

High

729158

VPS50
Syndetin

1

0

High-throughput

0.513

High

729160

SNX18
Sorting nexin-18

1

0

High-throughput

0.513

High

729182

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.513

High

729186

RTEL1
Regulator of telomere elongation helicase 1

1

0

High-throughput

0.513

High

174677

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

729065

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

5

Small-scale

0.501

High

729095

RABE1
Rab GTPase-binding effector protein 1

1

2

High-throughput

0.489

High

729116

PHLB3
Pleckstrin homology-like domain family B member 3

1

8

High-throughput

0.489

High

729122

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

5

High-throughput

0.489

High

729067

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

6

High-throughput

0.484

High

124783

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

11

Small-scale

0.479

High

129224

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

133904

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

Small-scale

0.479

High

176396

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

8

High-throughput

0.479

High

197243

SERA
D-3-phosphoglycerate dehydrogenase

1

6

Small-scale

0.479

High

226692

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

260481

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.479

High

267925

EED
Polycomb protein EED

1

11

High-throughput

0.479

High

282558

RNF8
E3 ubiquitin-protein ligase RNF8

1

13

High-throughput

0.479

High

298221

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

302974

HEXI1
Protein HEXIM1

1

17

High-throughput

0.479

High

312501

ARI2
E3 ubiquitin-protein ligase ARIH2

1

17

High-throughput

0.479

High

338041

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

352512

TNFA
Tumor necrosis factor

1

5

High-throughput

0.479

High

353385

PIGR
Polymeric immunoglobulin receptor

1

1

Small-scale

0.479

High

379075

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

386217

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

414582

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

3

Small-scale

0.479

High

428944

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.479

High

450745

F16P1
Fructose-1,6-bisphosphatase 1

1

4

High-throughput

0.479

High

453190

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

488599

ARAF
Serine/threonine-protein kinase A-Raf

1

6

High-throughput

0.479

High

528683

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.479

High

610265

CBL
E3 ubiquitin-protein ligase CBL

1

11

High-throughput

0.479

High

611385

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

19

Small-scale

0.479

High

666021

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

669289

EF1D
Elongation factor 1-delta

1

1

Small-scale

0.479

High

683876

1433S
14-3-3 protein sigma

1

19

Small-scale

0.479

High

708564

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.479

High

718555

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

729044

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.479

High

729045

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

729047

EPS15
Epidermal growth factor receptor substrate 15

1

11

High-throughput

0.479

High

729048

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

729050

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.479

High

729051

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

729052

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.479

High

729054

HDGF
Hepatoma-derived growth factor

1

1

High-throughput

0.479

High

729057

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

729058

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

729060

MGN
Protein mago nashi homolog

1

3

High-throughput

0.479

High

729061

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

729062

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

729064

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

729066

ARF5
ADP-ribosylation factor 5

1

3

High-throughput

0.479

High

729069

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

729072

ARL16
ADP-ribosylation factor-like protein 16

1

9

High-throughput

0.479

High

729073

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

729083

ARFRP
ADP-ribosylation factor-related protein 1

1

7

High-throughput

0.479

High

729084

DX39B
Spliceosome RNA helicase DDX39B

1

20

Small-scale

0.479

High

729088

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

729092

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

729093

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

15

High-throughput

0.479

High

729098

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

729104

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

5

High-throughput

0.479

High

729105

MIDN
Midnolin

1

2

High-throughput

0.479

High

729112

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

729117

PRP8
Pre-mRNA-processing-splicing factor 8

1

8

High-throughput

0.479

High

729119

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

7

High-throughput

0.479

High

729121

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

729125

MEPCE
7SK snRNA methylphosphate capping enzyme

1

11

High-throughput

0.479

High

729132

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

729135

RBM45
RNA-binding protein 45

1

1

High-throughput

0.479

High

729137

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

3

Small-scale

0.479

High

729138

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.479

High

729142

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.479

High

729143

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

729146

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.479

High

729147

KAT2A
Histone acetyltransferase KAT2A

1

1

High-throughput

0.479

High

729150

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

729151

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

7

Small-scale

0.479

High

729152

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

729153

AP2M1
AP-2 complex subunit mu

1

8

High-throughput

0.479

High

729154

RNF31
E3 ubiquitin-protein ligase RNF31

1

16

High-throughput

0.479

High

729157

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

729162

NECD
Necdin

1

5

High-throughput

0.479

High

729164

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

729165

ACE2
Angiotensin-converting enzyme 2

1

6

High-throughput

0.479

High

729167

TRI31
E3 ubiquitin-protein ligase TRIM31

1

12

High-throughput

0.479

High

729168

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

8

Small-scale

0.479

High

729169

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

729172

DDX24
ATP-dependent RNA helicase DDX24

1

17

High-throughput

0.479

High

729174

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

729176

RC3H2
Roquin-2

1

12

High-throughput

0.479

High

729177

NMRL1
NmrA-like family domain-containing protein 1

1

2

High-throughput

0.479

High

729179

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

10

High-throughput

0.479

High

729180

ANLN
Anillin

1

11

High-throughput

0.479

High

729184

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

729189

HDAC6
Histone deacetylase 6

1

12

High-throughput

0.479

High

729190

KS6B2
Ribosomal protein S6 kinase beta-2

1

6

High-throughput

0.479

High

729192

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

729193

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.479

High

729195

FBXL4
F-box/LRR-repeat protein 4

1

2

Small-scale

0.479

High

729196

FAF1
FAS-associated factor 1

1

4

High-throughput

0.479

High

729200

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

182582

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

729089

LASP1
LIM and SH3 domain protein 1

1

0

Small-scale

0.458

High

729100

CRY1
Cryptochrome-1

1

0

High-throughput

0.458

High

729106

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

146892

AQP7
Aquaporin-7

1

1

Small-scale

0.445

High

275381

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

305999

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

496447

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

729059

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

729068

ANK2
Ankyrin-2

1

11

High-throughput

0.445

High

729075

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.445

High

729107

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

729140

EXPH5
Exophilin-5

1

1

High-throughput

0.445

High

729173

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

729175

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

20

High-throughput

0.445

High

595979

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

729049

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

729055

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

729056

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

729090

Q149M6
Exophilin 5

1

1

High-throughput

0.437

High

729102

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

3

Small-scale

0.437

High

729118

LRC31
Leucine-rich repeat-containing protein 31

1

7

High-throughput

0.437

High

729123

ASXL2
Putative Polycomb group protein ASXL2

1

8

High-throughput

0.437

High

729124

KCTD9
BTB/POZ domain-containing protein KCTD9

1

2

High-throughput

0.437

High

729156

DIRA2
GTP-binding protein Di-Ras2

1

2

Small-scale

0.437

High

729163

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

6

High-throughput

0.437

High

729170

ASXL3
Putative Polycomb group protein ASXL3

1

5

High-throughput

0.437

High

729183

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

729199

AAR2
Protein AAR2 homolog

1

6

High-throughput

0.437

High

729201

INSI2
Insulin-induced gene 2 protein

1

7

High-throughput

0.437

High

952

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

729139

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

47921

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.279

Low

312783

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

0

High-throughput

0.279

Low

729074

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

729087

BLTP2
Bridge-like lipid transfer protein family member 2

1

0

High-throughput

0.279

Low

729115

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.279

Low

729144

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.279

Low

729187

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.279

Low

729194

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024