HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	29251248, 20562859
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 1319
+	Hs
		808068 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808265 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808272 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808254 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808261 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		1299634 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1192207 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Sc
		745993 ATG8_YEAST (1-116): 9.18e-59: 178: 55.17		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41
+	Ce
		1095399 LGG2_CAEEL (4-116): 4.59e-39: 128: 33.04		WWP1_CAEEL (609-799): 5.56e-29: 127: 27.04