HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: TBC25 (Q3MII6)
TBC1 domain family member 25
Gene: TBC1D25

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.701

Property	Details
Experiments	26902585, 21383079, 28514442, 33961781
Identification Methods	pull down, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0031410 - cytoplasmic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 688
+	Hs
		891174 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		TBC25_HUMAN (1-688): 0: 735: 100.00
+	Hs
		1109690 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBC25_HUMAN (1-688): 0: 735: 100.00
+	Hs
		1109691 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		TBC25_HUMAN (1-688): 0: 735: 100.00
+	Hs
		1315253 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TB10A_HUMAN (127-614): 4.12e-95: 305: 16.53
+	Hs
		891232 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11
+	Hs
		306240 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11
+	Hs
		1253208 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBC15_HUMAN (137-475): 2.54e-86: 287: 31.11
+	Dm
		1364630 Q9VEG5_DROME (1-116): 5.35e-54: 166: 77.59		Q9VPL5_DROME (112-475): 1.79e-78: 266: 27.08
+	Hs
		1198509 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBCD1_HUMAN (78-609): 9.38e-74: 260: 16.42
+	Hs
		891183 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		TBC9B_HUMAN (99-543): 2.54e-69: 248: 15.60
+	Hs
		1117430 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TB10B_HUMAN (114-617): 1.78e-72: 252: 15.89
+	Hs
		1328034 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBC17_HUMAN (194-550): 1.7e-72: 249: 31.22
+	Hs
		1146079 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBC9B_HUMAN (99-543): 2.54e-69: 248: 15.60
+	Hs
		891196 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		TBCD9_HUMAN (152-445): 1.51e-64: 234: 17.79
+	Sc
		746044 ATG8_YEAST (1-116): 9.18e-59: 178: 55.17		GYP1_YEAST (129-433): 1.75e-65: 229: 18.45
+	Hs
		1170417 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBCD9_HUMAN (152-445): 1.51e-64: 234: 17.79
+	Hs
		1252977 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		TBC16_HUMAN (159-437): 2.71e-66: 234: 34.16
+	Hs
		1117431 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		TB10B_HUMAN (114-617): 1.78e-72: 252: 15.89
+	Hs
		1146080 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		TBC9B_HUMAN (99-543): 2.54e-69: 248: 15.60
+	Hs
		1170419 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		TBCD9_HUMAN (152-445): 1.51e-64: 234: 17.79